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- Title
Ameliorative Effect of Ginger on Blood Glucose Levels and Cardiac TCA Cycle Enzymes Activity in STZ Induced Diabetic Rat.
- Authors
Nagendra Kumar, D. Veera; Mohan, K. Chandra; Rao, C. Narasimha; Krishnaiah, C. Venkata; Srineetha, U.; Sachidevi, P.
- Abstract
This study aimed to investigate the effects of ginger administration on altered blood glucose levels, cytosolic and mitochondrial enzymes (TCA cycle enzymes) activity in streptozotocin-induced diabetes rats. The study divided Wistar strain rats into five groups: normal control, ginger treated, diabetic control, diabetic plus ginger treated, and diabetic plus glibenclamide treated groups. The diabetic group had significantly elevated blood glucose levels, which were significantly lowered by ginger administration. The cytosolic enzyme G6PDH activity was significantly (P<0.001) decreased along with a significant increase in the LDH activity in diabetic rats heart tissue. The activities of SDH, MDH, GDH in the heart tissue of diabetic rats were significantly decreased, but the daily oral treatment of ginger to diabetic rats for thirty days reversed the above changes in a significant (P<0.001) manner. The study demonstrated that an ethanolic extract of ginger could lower blood glucose levels, improve enzyme activities and body weight in diabetic rats. This suggests that ginger extracts could be used as a cardio-protective supplement to reverse diabetic-induced complications.
- Subjects
HEART beat; GINGER; GLYCEMIC control; LABORATORY rats; ENZYMES; BLOOD sugar; HYPERGLYCEMIA
- Publication
Journal of Advanced Zoology, 2023, Vol 44, p1238
- ISSN
0253-7214
- Publication type
Article
- DOI
10.17762/jaz.v44is-5.1194