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- Title
Topical Administration of Aloe vera Extract Gel Increased the Number of Macrophages and Epithelialization in UVB-Induced Sunburn.
- Authors
Retnowati, Ersje; Dharmana, Edi; Chodidjah
- Abstract
INTRODUCTION: The UVB exposure may cause sunburn (second degree burn). Aloe vera (AV) is widely used in wound healing, including sunburn. OBJECTIVE: To evaluate the effect of topical Aloe vera extract gel on the number of macrophages and epithelialization in UVB induced sunburn. METHODS: This posttest only-control group design used twenty female BALB/c mice with UVB-induced sunburn randomly divided into 4 groups. Control groups (Cntrl-G) were given a base gel. Group AV-25, AV- 50, and AV-75 were topically treated with Aloe vera gel at the concentration of 25%, 50% and 75% respectively for 5 days. On day 5, after terminated, the samples of skin tissue were prepared for histological study using hematoxlyin eosin (HE) staining. Data were analyzed using one way ANOVA, Posthoc LSD and Pearson correlation. RESULTS: ANOVA analysis showed that the number of macrophages and epithelialization among groups was a significantly difference (p <0.05). Post hoc analysis demonstrated that the mean number of macrophage in AV-75 (6.50), AV-50 (5.13), and AV-25 (3.93) were significantly higher compared to that of Cntrl-G (2.93). The mean of epithelialization AV-75% (25.35), AV-50 (18.15), and AV-25 (15.38), were significantly (p <0.05) higher compared to that of Cntrl-G (9.30). The Pearson correlation test indicated that there is a strong positive correlation (0.88) between the number of macrophages and epithelialization (p <0.05). CONCLUSION: The topical administration of Aloe vera gel extract for five days increased the number of macrophages and epithelialization in sunburned UVB induced sun burn.
- Publication
Sains Medika Journal of Medical & Health, 2019, Vol 10, Issue 1, p15
- ISSN
2085-1545
- Publication type
Article