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- Title
Vision-related quality of life and visual function following intravitreal bevacizumab injection for persistent diabetic macular edema after vitrectomy.
- Authors
Okamoto, Yoshifumi; Okamoto, Fumiki; Hiraoka, Takahiro; Oshika, Tetsuro
- Abstract
Purpose: To investigate the vision-related quality of life (VR-QOL) and visual function in patients undergoing intravitreal injection of bevacizumab (IVB) for persistent diabetic macular edema (DME) after vitrectomy. Methods: This institutional study enrolled 20 consecutive patients (20 eyes) who had received 1.25 mg IVB for persistent macular edema after vitrectomy for DME at least 3 months previously. Visual function and VR-QOL were measured before, and 1 and 3 months after IVB. Measurements included the logarithm of the minimum angle of resolution (logMAR), best corrected visual acuity (BCVA), letter contrast sensitivity, severity of metamorphopsia using M-CHARTS, central retinal thickness using optical coherence tomography, and VR-QOL with the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). Results: One month after IVB, statistically significant improvements were observed in central retinal thickness, letter contrast sensitivity, and the VFQ-25 'mental health' subscale score ( P < 0.05, Dunnett test). LogMAR BCVA, metamorphopsia, and the VFQ-25 composite score did not improve significantly. Three months after IVB, there were no significant improvements in any parameters examined. Conclusions: Intravitreal bevacizumab injection for persistent DME after vitrectomy temporarily improved central retinal thickness, contrast sensitivity, and the psychometric aspect of the VR-QOL, but these effects did not last for over 3 months.
- Subjects
QUALITY of life; BEVACIZUMAB; EDEMA; VITRECTOMY; PEOPLE with visual disabilities; VISUAL acuity; OPTICAL coherence tomography
- Publication
Japanese Journal of Ophthalmology, 2014, Vol 58, Issue 4, p369
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-014-0323-7