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- Title
Cyclosporine A inhibits acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide
- Authors
Mazzanti, Cinthia M.; Spanevello, Roselia; Ahmed, Musthaq; Schmatz, Roberta; Mazzanti, Alexandre; Salbego, Fabiano Z.; Graça, Dominguita L.; Sallis, Eliza S.V.; Morsch, Vera M.; Schetinger, Maria Rosa C.
- Abstract
Abstract: Cyclosporine A is the major immunosuppressive agent used for organ transplantation and for the treatment of a variety of autoimmune disorders such as multiple sclerosis. In this work, we investigated the effect of the cyclosporine A on the acetylcholinesterase activity in the cerebral cortex, striatum, hippocampus, hypothalamus, cerebellum and pons of the rats experimentally demyelinated by ethidium bromide. Rats were divided into four groups: I control (injected with saline), II (treated with cyclosporine A), III (injected with 0.1% ethidium bromide) and IV (injected with 0.1% the ethidium bromide and treated with cyclosporine A). The results showed a significant inhibition (p <0.05) of acetylcholinesterase activity in the groups II, III and IV in all brain structures analyzed. In the striatum, hippocampus, hypothalamus and pons the inhibition was greater (p <0.005) when ethidium bromide was associated with cyclosporine A. In conclusion, the present investigation demonstrated that cyclosporine A is an inhibitor of acetylcholinesterase activity and this effect is increased after an event of toxic demyelination of the central nervous system.
- Subjects
CYCLOSPORINE; ACETYLCHOLINESTERASE; LABORATORY rats; NEUROSCIENCES
- Publication
International Journal of Developmental Neuroscience, 2007, Vol 25, Issue 4, p259
- ISSN
0736-5748
- Publication type
Article
- DOI
10.1016/j.ijdevneu.2007.02.005