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- Title
Sensitization to Food and Aero-Allergens in Children with Coeliac Disease Assessed with the Use of a Multiplex Molecular Diagnostic Technique.
- Authors
Knyziak-Mędrzycka, Izabela; Cukrowska, Bożena; Nazar, Wojciech; Bierła, Joanna Beata; Janeczek, Kamil; Krawiec, Paulina; Gromek, Weronika; Wysokiński, Mariusz; Konopka, Ewa; Trojanowska, Ilona; Smolińska, Sylwia; Majsiak, Emilia
- Abstract
(1) Background. Coeliac disease (CD) often co-occurs with autoimmune conditions or genetic syndromes, but there are few studies on the co-existence of CD and immunoglobulin E (IgE)-mediated allergies. The purpose of this study was to assess sensitization to food and aero-allergens in pediatric patients with CD. (2) Methods. A multiplex ALEX®2 test was used to determine specific IgEs (sIgEs). (3) Results. The study included 108 children newly diagnosed with CD. Allergen extract- and/or allergen molecule-sIgEs were detected in 49.1% of children. Most children (41.5%) were sensitized to both inhalant and food allergens. The three most common aero-allergens (timothy pollen, ryegrass, silver birch) were molecules Phl p 1, Lol p 1, and Bet v 1. The most common food allergens (hazelnut, apple, and peanut) were Cor a 1, Mal d 1, and Ara h 8 molecules of the PR-10 subfamily. Patients were not sensitized to cereal allergens containing gluten. Spearman's rank correlation analysis of sensitized patients showed a significant positive relationship (r = 0.31) between the patients' age and the occurrence of positive sIgEs (≥0.3 kUA/L) for inhalant allergen molecules (p = 0.045). In sensitized patients, mainly symptoms of inhalant allergy were observed, such as hay fever, conjunctivitis, and bronchial asthma. (4) Conclusions. The current study indicates the co-occurrence of IgE sensitization to food and inhalant allergens in children with CD. The study highlights the need to take a closer look at the diagnosis of IgE-mediated allergy in patients with CD, which may help in their care and lead to a better understanding of the relationship between CD and IgE-mediated allergy.
- Subjects
JUVENILE diseases; CHILD nutrition; CELIAC disease; IMMUNOGLOBULIN E; ALLERGIC rhinitis; PEANUT allergy; CHILD patients
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 10, p2992
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13102992