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- Title
Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa.
- Authors
Martínez, M E; Heddens, D; Earnest, D L; Bogert, C L; Roe, D; Einspahr, J; Marshall, J R; Alberts, D S
- Abstract
<bold>Background: </bold>Evidence suggests a relationship between prostaglandin levels in colonic mucosa and risk of colon cancer. Physical inactivity and a higher body mass index (BMI; weight in kilograms divided by [height in meters]2) have been consistently shown to increase risk of this cancer. We investigated whether higher levels of leisure-time physical activity or a lower BMI was associated with lower concentrations of prostaglandin E2 (PGE2) in rectal mucosa.<bold>Methods: </bold>This study was conducted in 41 men and 22 women, 42-78 years of age, with a history of polyps, who participated in a randomized clinical trial testing the effects of piroxicam on rectal mucosal PGE2 levels. An [125I]PGE2 radioimmunoassay kit was used to determine PGE2 levels in samples of extracted rectal mucosa collected before randomization. Leisure-time physical activity was assessed through a self-administered questionnaire collected at baseline. The reported time spent at each activity per week was multiplied by its typical energy expenditure, expressed in metabolic equivalents (METs), to yield a MET-hours per week score. A repeated measures model was used to assess the effect of BMI and physical activity as predictors of PGE2 concentration. All statistical tests were two-sided.<bold>Results: </bold>After adjustment for age, a higher BMI was associated with higher PGE2 levels (P = .001). A higher level of leisure-time physical activity was inversely associated with PGE2 concentration (P<.03). An increase in BMI from 24.2 to 28.8 kg/m2 was associated with a 27% increase in PGE2. An increase in activity level from 5.2 to 27.7 MET-hours per week was associated with a 28% decrease in PGE2.<bold>Conclusions: </bold>Physical activity and obesity may alter the risk of colon cancer through their effects on PGE2 synthesis.
- Publication
JNCI: Journal of the National Cancer Institute, 1999, Vol 91, Issue 11, p950
- ISSN
0027-8874
- Publication type
journal article
- DOI
10.1093/jnci/91.11.950