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- Title
Observation on the Curative Effect of Bdesonide/formoterol plus Tiotropium Bromide on Group C and D COPD Patients.
- Authors
LI Hai-feng; LENG Jing; HUANG Wei
- Abstract
Objective To evaluate the curative effect of budesonide/formoterol plus tiotropium bromide (tiotropium) on group C and D COPD patients. Methods In this 6-month, randomized, double-blind study, 157 subjects, 50 years of age or older, received budesonide/formoterol plus tiotropium (n = 78) or budesonide/formoterol alone (n =79). All patients received oxygen therapy, theophylline, and nutritional support as adjunct therapies. Albuterol was used as needed for symptom relief throughout the treatment period. The effect and adverse reactions were compared between treatment group and control group after 6 months of treatment. Results Over the treatment period, budesonide/formoterol plus tiotropium significantly increased postdose FEV1, MMRC, and 6MWD versus budesonide/formoterol alone (both P < 0.05). Conclusions In patients with chronic obstructive pulmonary disease, budesonide/formoterol plus tiotropium provides rapid and sustained improvements in clinical symptoms, health status, and activities, and reduces severe exacerbations budesonide/formoterol alone.
- Subjects
OBSTRUCTIVE lung diseases patients; BUDESONIDE; FORMOTEROL; PARASYMPATHOLYTIC agents; BRONCHODILATOR agents; THERAPEUTICS
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 12, p62
- ISSN
2095-610X
- Publication type
Article