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- Title
Expression of BMP-2 in Clip-type Spinal Cord Injury Rats Model after Electro-acupuncture Treatment.
- Authors
LI Jing-hui; XIE Yong; LIU Yu; HUAN Hui; WU Hai-yin; YU Hua-lin; BAI Peng
- Abstract
Objective Investigate the expression of BMP-2 in spinal cord injury ( SCI) rats after the electro-acupuncture (EA) treatment in order to provide experimental basis for electro-acupuncture treatment of SCI. Methods 36 SD rats were randomly divided into the SCI group, the SHAM group and the EA group. Aneurysm-clipping (temporary) method was used to make up an acute SCI model. The injured myoloid tissues were obtained at the 7th, 14th, 21st and 28th day respectively after injury. The expression of the BMP-2 in the injured spinal cord tissue in each group was observed by Western blotting. Results The expression of BMP-2 was obviously enhanced after injury for 7∼14 days, and this high-level expression sustained until the 28th days. The expression of BMP -2 in the EA group was lower than that in the SCI group with statistically significant difference (P < 0.05), and the difference increased over time. Conclusion Electric-acupuncture could promote the functional recovery after spinal cord injury by inhibiting the expression of BMP-2. And the results have provided the experimental basis for electro-acupuncture treatment of spinal cord injury.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 3, p19
- ISSN
2095-610X
- Publication type
Article