We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study.
- Authors
Braun, Joseph M.; Chen, Aimin; Romano, Megan E.; Calafat, Antonia M.; Webster, Glenys M.; Yolton, Kimberly; Lanphear, Bruce P.
- Abstract
<bold>Objective: </bold>To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.<bold>Methods: </bold>Data are from a prospective cohort in Cincinnati, Ohio (HOME Study). Perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids were measured in prenatal serum samples. Differences were measured in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n = 204) and BMI between 2-8 years of age (n = 285) according to PFAS concentrations.<bold>Results: </bold>Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI: 1.7, 6.9) and 3rd tercile (2.2; 95% CI: -0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2 to 8 years compared to children in the 1st tercile (P < 0.05). PFOS, PFNA, and PFHxS were not associated with adiposity.<bold>Conclusions: </bold>In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2-8 years.
- Subjects
OHIO; CHILDHOOD obesity; FLUOROALKYL compounds; PERFLUOROOCTANOIC acid; PERFLUOROOCTANE sulfonate; BLOOD serum analysis; BODY mass index; WAIST circumference; COHORT analysis; DOSE-effect relationship in pharmacology; FLUOROCARBONS; LONGITUDINAL method; SULFUR acids; PRENATAL exposure delayed effects
- Publication
Obesity (19307381), 2016, Vol 24, Issue 1, p231
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21258