We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Decreased Serum Creatinine Concentration Is Associated With Short Telomeres of Adipose Tissue Cells.
- Authors
Fernández-Real, J. M.; Moreno-Navarrete, J. M.; Ortega, F.; Ricart, W.
- Abstract
Decreased serum creatinine concentration has been recently described to constitute a new risk factor of type 2 diabetes. Increased free radicals have been consistently associated with decreased serum creatinine and with cellular senescence. Telomere length is considered as a biological marker for senescence. We aimed to study the association of telomere length with serum creatinine. Telomere length of subcutaneous adipose tissue cells was measured in a sample of obese and nonobese subjects (n = 49). Telomere length of subcutaneous adipose tissue cells was positively associated with serum creatinine (r = 0.40, P = 0.004), i.e., the lower the telomere length, the lower the serum creatinine, but not with glomerular filtration rate (GFR). In addition, telomere length was negatively associated with BMI (r = −0.45, P = 0.001) and systolic blood pressure (r = −0.41, P = 0.003). In a multiple linear regression analysis, BMI (P = 0.005), systolic blood pressure (P = 0.01) and telomere length (P = 0.03) independently contributed to 37% of serum creatinine variance after controlling for sex and age. In conclusion, the association of serum creatinine with a marker of cellular senescence suggests an underlying mechanism influencing both decreased serum creatinine and increased risk of type 2 diabetes.
- Subjects
SERUM; CREATININE; DIABETES; TELOMERES; ADIPOSE tissues
- Publication
Obesity (19307381), 2011, Vol 19, Issue 7, p1511
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2011.31