Based on the single factor experiments, the response surface methodology (RSM) was employed to optimize the extractions of polysaccharides from Fuling and its main ingredients were analyzed. The results of optimum extraction conditions were as follow: the extraction temperature 50℃, stress 21.78 MPa, concentration of cosolvent 83.19%. Under these conditions, the average extraction yield was 3.104%. The optimization of Fuling extraction process technology was reasonable and feasible.