We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion.
- Authors
Sato, Yuta; Kudo, Shin-Ei; Ichimasa, Katsuro; Matsudaira, Shingo; Kouyama, Yuta; Kato, Kazuki; Baba, Toshiyuki; Wakamura, Kunihiko; Hayashi, Takemasa; Kudo, Toyoki; Ogata, Noriyuki; Mori, Yuichi; Misawa, Masashi; Toyoshima, Naoya; Ishigaki, Tomoyuki; Yagawa, Yusuke; Nakamura, Hiroki; Sakurai, Tatsuya; Shakuo, Yukiko; Suzuki, Kenichi
- Abstract
With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. A total of 741 patients with T1 CRCs that were resected surgically between April 2001 and October 2016 in our hospital were divided into two groups: With SLVI and without SLVI. Clinicopathological features compared between the two groups were patient's gender, age, tumor size, location, morphology, lymphovascular invasion, tumor differentiation, tumor budding and lymph node metastasis. The incidence of T1 CRCs with SLVI was 0.9% (7/741). All cases with SLVI were found in the sigmoid colon or rectum. T1 CRCs with SLVI showed significantly higher rates of lymphovascular invasion than those without SLVI (P<0.01). In conclusion, lymphovascular invasion was a significant risk factor for SLVI in T1 CRCs, and for which surgical colectomy was necessary. The Japanese guidelines are appropriate regarding SLVI. Registered in the University Hospital Medical Network Clinical Trials Registry (UMIN000027097).
- Subjects
COLON cancer treatment; COLON cancer patients; CANCER invasiveness; CANCER treatment; DISEASE management
- Publication
Oncology Letters, 2018, Vol 16, Issue 6, p7264
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2018.9527