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- Title
STUNNING THE NEURAL NEXUS: MECHANISMS OF GENERAL ANESTHESIA.
- Authors
Villars, Penelope S.; Kanusky, Joseph T.; Dougherty, Thomas B.
- Abstract
General anesthesia requires managing a complex array of anesthetic agents that act on an intricate web of neural connections of neural nexus, Both inhaled and Intravenous anesthetics must intervene at some level of the neural nexus that provides for amnesia, immobility, hypnosis, and suppression of noxious reflexes. These interactions occur at the spinal and supraspinal level and involve spinal pathways and centers of arousal and memory formation centrally. Current research does not support the notion of a unitary mechanism of action for general anesthetics, but rather that anesthetics act by altering neuronal ion channels and neural communication. In general, anesthetics act by either enhancing inhibitory transmission or blocking excitatory conduction in neural impulses. The potent inhaled agents and most intravenous agents enhance the inhibitory λ-aminobutyric acid subtype A (GABAA) and glycine channels and depress the excitatory neuronal nicotinic acetylcholine (nnACh) receptors. Nitrous oxide and ketamine act primarily by depressing the excitatory N-methyl-D-aspartate (NMDA) receptors and enhancing the opioid μ receptors. The extent, distribution, and subunit composition of these receptors determine the effects of various anesthetic agents on an individual patient. This variability, both within the patient and among the mechanisms of action of anesthetics, provides a reasonable degree of flexibility to the clinical practice of anesthesia.
- Subjects
ANESTHESIA; GAP junctions (Cell biology); CELL junctions; ANESTHESIOLOGY; SURGERY; MEMORY
- Publication
AANA Journal, 2004, Vol 72, Issue 3, p197
- ISSN
0094-6354
- Publication type
Article