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- Title
Lower relapse incidence with HAPLO versus MSD or MUD HCTs for AML patients with KMT2A rearrangement: a study from the Global Committee and the ALWP of the EBMT.
- Authors
Ye, Yishan; Labopin, Myriam; Chen, Jia; Wu, Depei; Gedde-Dahl Sr., Tobias; Blaise, Didier; Socie, Gérard; Forcade, Edouard; Salmenniemi, Urpu; Maury, Sébastien; Versluis, Jurjen; Bazarbachi, Ali; Nagler, Arnon; Brissot, Eolia; Li, Lin; Luo, Yi; Shi, Jimin; Ciceri, Fabio; Huang, He; Mohty, Mohamad
- Abstract
A study published in the Blood Cancer Journal examined the outcomes of allogeneic hematopoietic stem cell transplantation (HCT) in adult patients with adverse-risk acute myeloid leukemia (AML) and KMT2A rearrangement. The study found that haploidentical donor HCT (Haplo-HCT) had a lower relapse incidence compared to matched sibling donor (MSD) or matched unrelated donor (MUD) transplants. The study also investigated the prognostic value of different KMT2A fusion partners. The findings suggest that Haplo-HCT may be beneficial for AML patients with adverse-risk KMT2A rearrangement, excluding t(9;11), in terms of relapse prevention.
- Subjects
ACUTE myeloid leukemia; MUD; CORD blood; HEMATOPOIETIC stem cell transplantation
- Publication
Blood Cancer Journal, 2024, Vol 14, Issue 1, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-024-01072-0