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- Title
A novel Iowa–Mayo validated composite risk assessment tool for allogeneic stem cell transplantation survival outcome prediction.
- Authors
Nadiminti, Kalyan; Langer, Kimberly; Shabbir, Ehsan; Hefazi, Mehrdad; Dozeman, Lindsay; Jethava, Yogesh; Loeffler, Bradley; AlKhateeb, Hassan B.; Litzow, Mark; Patnaik, Mrinal; Shah, Mithun; Hogan, William; Farooq, Umar; Silverman, Margarida; Mott, Sarah L.
- Abstract
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for many hematologic conditions and is associated with considerable morbidity and mortality. Therefore, prognostic tools are essential to navigate the complex patient, disease, donor, and transplant characteristics that differentially influence outcomes. We developed a novel, comprehensive composite prognostic tool. Using a lasso-penalized Cox regression model (n = 273), performance status, HCT-CI, refined disease-risk index (rDRI), donor and recipient CMV status, and donor age were identified as predictors of disease-free survival (DFS). The results for overall survival (OS) were similar except for recipient CMV status not being included in the model. Models were validated in an external dataset (n = 378) and resulted in a c-statistic of 0.61 and 0.62 for DFS and OS, respectively. Importantly, this tool incorporates donor age as a variable, which has an important role in HSCT outcomes. This needs to be further studied in prospective models. An easy-to-use and a web-based nomogram can be accessed here: https://allohsctsurvivalcalc.iowa.uiowa.edu/.
- Subjects
STEM cell transplantation; SURVIVAL rate; HEMATOPOIETIC stem cell transplantation; TREATMENT effectiveness; CELL survival
- Publication
Blood Cancer Journal, 2021, Vol 11, Issue 11, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-021-00573-6