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- Title
Association of an miR-502-binding site polymorphism in the 3′-untranslated region of SET8 with colorectal cancer.
- Authors
Liu, Shuang; Dong, Hailing; Wu, Jianhua; Wang, Cuiju
- Abstract
The histone methyltransferase SET8 is regulated by microRNA-502 through the binding site in its 3′-untranslated region, and the rs16917496 polymorphism at the miR-502-binding site in the SET8 gene has been implicated in a number of cancer types. The rs16917496 polymorphism including CC, CT and TT genotypes was analyzed in patients with colorectal cancer; the CC genotype was identified to be independently associated with longer post-operative survival times using multivariate analysis (relative risk, 2.406; 95% confidence interval, 1.017–5.691; P=0.046). In addition, decreased SET8 expression was associated with the SET8 CC genotype and longer survival times for patients with colorectal cancer. The results of the present study indicated that miR-502 mediates SET8 expression at least partly by altering the binding affinity between miR-502 and SET8 so as to modify the colorectal cancer outcome. The results indicate that SET8 may be a novel target for colorectal cancer therapy.
- Subjects
COLORECTAL cancer; BINDING sites; MULTIVARIATE analysis; CONFIDENCE intervals; CANCER treatment
- Publication
Oncology Letters, 2019, Vol 17, Issue 4, p3960
- ISSN
1792-1074
- Publication type
Article