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- Title
MicroRNAs and cancer: Key paradigms in molecular therapy (Review).
- Authors
Tan, Weige; Liu, Bodu; Qu, Shaohua; Liang, Gehao; Luo, Wei; Gong, Chang
- Abstract
MicroRNAs (miRNAs) are a type of small non‑coding RNA molecule that performs an important role in post‑transcriptional gene regulation. Since miRNAs were first identified in 1993, a number of studies have demonstrated that they act as tumor suppressors or oncogenes in human cancer, including colorectal, lung, brain, breast and liver cancer, and leukemia. Large high‑throughput studies have previously revealed that miRNA profiling is critical for the diagnosis and prognosis of patients with cancer, while certain miRNAs possess the potential to be used as diagnostic and prognostic biomarkers or therapeutic targets in cancer. The present study reviews the studies and examines the roles of miRNAs in cancer diagnosis, prognosis and treatment, and discusses the potential therapeutic modality of exploiting miRNAs.
- Subjects
CANCER genetics; TUMOR suppressor genes; CANCER diagnosis; MICRORNA; GENETIC transcription; GENE expression profiling
- Publication
Oncology Letters, 2018, Vol 15, Issue 3, p2735
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2017.7638