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- Title
Expression of FoxM1 and the EMT-associated protein E-cadherin in gastric cancer and its clinical significance.
- Authors
JING ZHANG; XIAO-YU CHEN; KE-JIAN HUANG; WEI-DONG WU; TAO JIANG; JUN CAO; LI-SHENG ZHOU; ZHENG-JUN QIU; CHEN HUANG
- Abstract
The aim of the present study was to investigate the expression of forkhead box M1 (FoxM1) and E-cadherin in tissues of gastric cancer in order to reveal any correlation between FoxM1, E-cadherin and clinicopathological parameters. The association between FoxM1 and E-cadherin in the development and progression of gastric cancer was also investigated. The expression of FoxM1 and E-cadherin in gastric cancer and adjacent normal tissue on tissue microarray was detected using immunohistochemistry. The clinicopathological significance of FoxM1 and E-cadherin in gastric cancer was explored, and the association between FoxM1 and E-cadherin was further examined using statistical techniques. In gastric cancer tissues, the expression of FoxM1 and E-cadherin was strongly positive, but it was weak in normal gastric mucosa. Overexpression of FoxM1 was evident in gastric cancer, and was associated with poor tumor differentiation (P<0.05), advanced tumor state (P<0.05) and lymph node (or distant) metastasis (P<0.05), whereas E-cadherin had the opposite effects. Furthermore, the correlation between FoxM1 and E-cadherin expression in gastric cancer tissue was negative. In conclusion, the high FoxM1 expression and low E-cadherin expression in gastric cancer tissue suggests that these proteins play a critical role in the development and progression of gastric cancer.
- Subjects
FORKHEAD transcription factors; CADHERINS; GASTRIC diseases; IMMUNOHISTOCHEMISTRY; LYMPH nodes
- Publication
Oncology Letters, 2016, Vol 12, Issue 4, p2445
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4917