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- Title
The PITT pathway: Keeping lysosomes young.
- Authors
Yang, Haoxiang; Tan, Jay Xiaojun
- Abstract
Cholesterol by itself protects lysosomal membrane, and lysosomal PS activates autophagy protein 2 (ATG2)-mediated lipid transfer for direct membrane repair. There are likely additional lipid remodelling events in lysosomal quality control.12 The PITT pathway is triggered by PI4P signalling that drives extensive ER-lysosome membrane contacts to support multiple lipid transfer processes for direct and rapid lysosomal repair. Lysosomes are essential subcellular organelles in animal cells discovered by Christian de Duve in 1950s.
- Subjects
LYSOSOMES; PREMATURE aging (Medicine); SMALL molecules
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 10, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1097