We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gene essentiality for tumour growth influences neoantigen‐directed immunoediting.
- Authors
Bang, Hyoeun; Park, Jae Soon; Kim, Jeong Yeon; Sung, Changhwan; An, Jinhyeon; Cho, Dae‐Yeon; Lee, Se‐Hoon; Shim, Seok Bo; Choi, Jung Kyoon; Kim, Kwoneel
- Abstract
Dear Editor, The outgrowth of clones not expressing tumour antigens is a well-known immune evasion mechanism of cancer.1 Here, we defined constitutive neoantigens according to the essentiality of their corresponding genes, which are essentially expressed for tumour growth even under immune selection. Gene essentiality for tumour growth influences neoantigen-directed immunoediting Comparison of differential neoantigen load in all genes (gray line in A), high fitness effect genes (blue bar in A), and low fitness effect genes (red bar in A). Consistent with the ICI cohort results, larger differences in neoantigen load were observed when genes with high patient-specific fitness effects were used for neoantigen counting (Figure 4A,B and Figures S13A, S13B, and S14).
- Subjects
GENOME editing; GENES
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 1, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.714