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- Title
Human and mouse non‐targeted metabolomics identify 1,5‐anhydroglucitol as SGLT2‐dependent glycemic marker.
- Authors
Kappel, Ben A.; Moellmann, Julia; Thiele, Kirsten; Rau, Matthias; Artati, Anna; Adamski, Jerzy; Ghesquiere, Bart; Schuett, Katharina; Romeo, Francesco; Stoehr, Robert; Marx, Nikolaus; Federici, Massimo; Lehrke, Michael
- Abstract
(D) Top 10 metabolites by two-sided t-test corrected for multiple testing by false discovery rate (FDR < 0.3) of human MI cohort serum metabolomics (left) and mice serum metabolomics (right). Human and mouse non-targeted metabolomics identify 1,5-anhydroglucitol as SGLT2-dependent glycemic marker Keywords: biomarker; metabolomics; SGLT2; type 2 diabetes EN biomarker metabolomics SGLT2 type 2 diabetes 1 7 7 07/01/21 20210601 NES 210601 Abbreviations 1,5-AG 1,5-anhydroglucitol AUC area under the curve BCAA branched-chain amino acid EMPA empagliflozin treatment HbA1c glycated hemoglobin MI myocardial infarction ROC receiver operating characteristic SGLT sodium-glucose cotransporter Metabolomics provide a powerful tool in the search for biomarkers and pathways related to a disease or in response to a drug therapy. In this study, we combined three different non-targeted serum metabolomics datasets in human and mice to explore pathways and biomarkers related to diabetes.
- Subjects
SODIUM-glucose cotransporters; METABOLOMICS; SODIUM-glucose cotransporter 2 inhibitors; BIOMARKERS
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 6, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.470