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- Title
The effect of topical crude coal tar treatment on unstimulated hairless hamster skin.
- Authors
Foreman, M. I.; Picton, W.; Lukowiecki, G. A.; Clark, C.
- Abstract
Topical treatment of hairless hamster skin with crude coal tar has been shown to induce epidermal thickening, an increased labelling index in the basal cell layer, an elevation in NADP-dependent glucose-6-phosphate dehydrogenase activity throughout the epidermis, an increased squame count, comedo formation, and atrophy of the sebaceous glands. Ultraviolet light fluorescence microscopy of sections of treated skin suggests that the hair follicle is an important route for skin penetration by coal tar.
- Subjects
GLUCOSE-6-phosphate dehydrogenase; DEHYDROGENASES; TAR; SKIN; FLUORESCENCE microscopy; HAIR
- Publication
British Journal of Dermatology, 1979, Vol 100, Issue 6, p707
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1979.tb08077.x