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- Title
The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome in ‘pure’ ductal carcinoma in situ of the breast.
- Authors
de Roos, M. A. J.; van der Vegt, B.; Peterse, J. L.; Patriarca, C.; de Vries, J.; de Bock, G. H.; Wesseling, J.
- Abstract
Aims: To classify MUC1 according to five predefined expression patterns in ductal carcinoma in situ (DCIS) and related clinicopathological parameters, coexpression of other biological markers and prognosis. Methods and results: With a manual tissue arrayer, 92% ( n = 80) of the 87 DCIS samples were successfully targeted. Immunohistochemistry was carried out for MUC1, oestrogen receptor (ER), progesterone receptor (PR), Her2/Neu, p53 and cyclin D1. Entire membrane expression was related to Her2/neu negativity ( P =0.042). Apical membrane expression was associated with low grade ( P = 0.027), Her2/neu negativity ( P = 0.014) and PR positivity ( P = 0.005). Focal cytoplasmic expression was related to high grade ( P = 0.006). Diffuse cytoplasmic expression was associated with high grade ( P = 0.004), large tumour size ( P = 0.046), Her2/neu positivity ( P =0.042) and cyclin D1 positivity ( P = 0.002). On the basis of these analyses the four patterns were reclassified as membranous or cytoplasmic expression. On multivariate analysis, cytoplasmic MUC1 expression (hazard ratio 8.5, 95% confidence interval 1.0, 73.0; P = 0.04) was the only independent predictor of local recurrence. Conclusions: Four patterns of MUC1 expression are recognized in DCIS that suggest a relationship to functional differentiation and can be simplified into two types that are clinically relevant and could therefore be helpful in the distinction between different subgroups of DCIS.
- Subjects
CELLULAR pathology; TUMOR markers; BIOMARKERS; IMMUNOHISTOCHEMISTRY; SEX hormones
- Publication
Histopathology, 2007, Vol 51, Issue 2, p227
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2007.02754.x