Reports on the medical case of a 33-year-old woman with malignant melanoma presenting as an ampullary tumor. Presentation with jaundice, pruritus, nausea and vomiting; Results of abdominal ultrasonography and biopsy of the ampullary tumor; Histological examination results; Digestive tract location of malignant melanoma; Diagnostic problems of the disease, such as the assessment of primary and metastatic nature.