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- Title
L-homoarginine is associated with decreased cardiovascular- and all-cause mortality.
- Authors
Mokhaneli, Maserame Cleopatra; Botha-Le Roux, Shan; Fourie, Carla Maria Theresia; Böger, Rainer; Schwedhelm, Edzard; Cornelia Mels, Catharina Martha
- Abstract
Background: Increasing evidence suggests that L-homoarginine, an endogenous analogue of the amino acid L-arginine, may have beneficial effects on vascular homeostasis. We examined whether L-homoarginine is associated with 10-year risk of all-cause and cardiovascular mortality in a black South African population. Methods: We included 669 black South African participants (mean age 59.5 years), 143 of whom died during the 10-year follow-up period. Mortality data were acquired via verbal autopsy. Plasma L-homoarginine (and other related markers) were analysed with liquid chromatography-tandem mass spectrometry. Results: Survivors had higher L-homoarginine levels compared with nonsurvivors (1.25 µM vs. 0.89 µM; P < .001). Multivariable Cox regression analyses revealed that higher plasma L-homoarginine predicted a reduction in 10-year cardiovascular (hazard ratio [HR] per SD increment, 0.61; 95% CI 0.50 to 0.75) and all-cause (hazard ratio [HR] per SD increment, 0.59; 95% CI 0.41 to 0.84) mortality risk. Conclusion: Higher L-homoarginine levels are associated with reduced risk of 10-year cardiovascular and all-cause mortality. Regulation of L-homoarginine levels as a therapeutic target in the management of cardiovascular disease should be investigated.
- Subjects
SOUTH Africa; MORTALITY; LIQUID chromatography-mass spectrometry; SOUTH Africans; CARDIOVASCULAR diseases; BLACK South Africans
- Publication
European Journal of Clinical Investigation, 2021, Vol 51, Issue 5, p1
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.13472