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- Title
Pulsed intravenous immunoglobulin therapy in refractory ulcerated livedoid vasculopathy: seven cases and a literature review.
- Authors
Kim, Eun Jee; Yoon, So Young; Park, Hyun Sun; Yoon, Hyun‐Sun; Cho, Soyun
- Abstract
Livedoid vasculopathy ( LV) is a thrombotic vasculopathy of the skin of unknown origin. No treatment has been validated in this indication, but case reports demonstrated successful use of intravenous immunoglobulins ( IVIg) in LV. We assessed the efficacy and tolerability of 2 g/kg IVIg therapy every month for 2∼3 cycles in patients with refractory LV. We analyzed the efficacy, side effects and recurrence after long-term follow-up (51.9 ± 14.0 months) in seven patients with LV treated with 2 g/kg of IVIg. Mean clinical score of sum of erythema, ulceration and pain index (each: 0-3) was 5.7 ± 0.9 before the therapy and significantly lower after therapy (1.1 ± 0.5) ( p = 0.001). Even after just one cycle of IVIg, the score decreased significantly from 5.7 ± 0.9 to 3.7 ± 0.9 ( p = 0.002), especially the pain score. In one patient, LV has not recurred for over 7 years; six patients experienced recurrence after a mean of 12.7 ± 2.8 months. Out of the six patients, two patients were re-administered IVIg whereas the others were well controlled by conventional therapy. We propose that IVIg is a rapid, effective, and safe therapeutic option in LV refractory to other treatment modalities.
- Subjects
THERAPEUTIC use of immunoglobulins; INTRAVENOUS immunoglobulins; ERYTHEMA; FIFTH disease; ROSACEA
- Publication
Dermatologic Therapy, 2015, Vol 28, Issue 5, p287
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/dth.12233