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- Title
Acute generalized exanthematous pustulosis and epidermal necrolysis differ in innate cytokine patterns.
- Authors
Lalevée, Sophie; Audureau, Etienne; Riou, Audrey; Colin, Audrey; Anquetin, Maxime; Barau, Caroline; Valeyrie‐Allanore, Laurence; Delfau‐Larue, Marie‐Hélène; Chosidow, Olivier; Wolkenstein, Pierre; Ingen‐Housz‐Oro, Saskia; Hüe, Sophie
- Abstract
This retrospective single-centre study involved patients with AGEP or EN referred to our reference centre between 2006 and 2015 who had blood samples collected as soon as possible, most of them within the first 5 days after admission with signed consent of the patients. We included 111 consecutive patients (63 women, mean age 47.3 ± 19 years): 27 had AGEP (24.3%) and 84 (75.7%) had EN, including 34 with SJS, 22 overlap syndrome and 28 TEN. Forty-nine EN patients (58%) received ciclosporin, and all AGEP patients received topical steroids. Cluster 1 contained a majority of AGEP and SJS patients (31.4% for each) and less severe disease, whereas cluster 3 contained a majority of TEN patients (54.5%).
- Subjects
CYTOTOXIC T cells; HIERARCHICAL clustering (Cluster analysis)
- Publication
Clinical & Experimental Allergy, 2019, Vol 49, Issue 9, p1258
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.13449