We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cortical thickness 20 years after diagnosis of anorexia nervosa during adolescence.
- Authors
Castro-Fornieles, Josefina; de la Serna, Elena; Calvo, Anna; Pariente, José; Andrés-Perpiña, Susana; Plana, Maria Teresa; Romero, Sonia; Flamarique, Itziar; Gárriz, Miguel; Bargalló, Núria
- Abstract
Objective: The objective of the present study is to evaluate cortical thickness (CT) abnormalities using FreeSurfer in adult subjects who had an onset of anorexia nervosa during their adolescence some 20 years previously, and to compare them with control subjects. Methods: Fifty-four participants, including 26 women who were diagnosed and treated for AN during adolescence some 20 years previously and 28 healthy women of similar age and geographical area were assessed using structured interviews and MRI scans. Prior AN subjects were divided into two groups depending on their current eating disorder status (recovered or not recovered from any eating disorder). In all subjects, CT was measured using FreeSurfer. Results: A significantly lower CT was observed in the eating disorder group than in the control group in the right post-central gyrus and the lateral occipital cortex. The recovered eating disorder group only had lower CT in the post-central gyrus. Within all subjects with prior AN, no correlations were found between lower CT in these areas and clinical variables. Discussion: CT is reduced some 20 years after diagnosis of AN especially in the parietal and precentral areas, even in subjects without any current ED diagnosis.
- Subjects
ANOREXIA nervosa; DIAGNOSIS; ADOLESCENCE; EATING disorders; ADULTS; BRAIN cortical thickness
- Publication
European Archives of Psychiatry & Clinical Neuroscience, 2021, Vol 271, Issue 6, p1133
- ISSN
0940-1334
- Publication type
Article
- DOI
10.1007/s00406-019-00992-4