We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Three-Year long-term outcome of 458 naturalistically treated inpatients with major depressive episode: severe relapse rates and risk factors.
- Authors
Seemüller, Florian; Meier, Sebastian; Obermeier, Michael; Musil, Richard; Bauer, Michael; Adli, Mazda; Kronmüller, Klaus; Holsboer, Florian; Brieger, Peter; Laux, Gerd; Bender, Wolfram; Heuser, Isabella; Zeiler, Joachim; Gaebel, Wolfgang; Riedel, Michael; Falkai, Peter; Möller, Hans-Jürgen
- Abstract
In randomized controlled trials, maintenance treatment for relapse prevention has been proven to be efficacious in patients responding in acute treatment, its efficacy in long-term outcome in 'real-world patients' has yet to be proven. Three-year long-term data from a large naturalistic multisite follow-up were presented. Severe relapse was defined as suicide, severe suicide attempt, or rehospitalization. Next to relapse rates, possible risk factors including antidepressant medication were identified using univariate generalized log-rank tests and multivariate Cox proportional hazards model for time to severe relapse. Overall data of 458 patients were available for analysis. Of all patients, 155 (33.6 %) experienced at least one severe relapse during the 3-year follow-up. The following variables were associated with a shorter time to a severe relapse in univariate and multivariate analyses: multiple hospitalizations, presence of avoidant personality disorder, continuing antipsychotic medication, and no further antidepressant treatment. In comparison with other studies, the observed rate of severe relapse during 3-year period is rather low. This is one of the first reports demonstrating a beneficial effect of long-term antidepressant medication on severe relapse rates in naturalistic patients. Concomitant antipsychotic medication may be a proxy marker for treatment resistant and psychotic depression.
- Subjects
MENTAL depression; THERAPEUTICS; DISEASE relapse; MENTAL depression risk factors; RANDOMIZED controlled trials; HEALTH outcome assessment; FOLLOW-up studies (Medicine); SUICIDAL behavior
- Publication
European Archives of Psychiatry & Clinical Neuroscience, 2014, Vol 264, Issue 7, p567
- ISSN
0940-1334
- Publication type
Article
- DOI
10.1007/s00406-014-0495-7