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- Title
Opposite actions of urotensin II and relaxin-2 on cellular expression of fibronectin in renal fibrosis: A preliminary experimental study.
- Authors
Cernaro, Valeria; Medici, Maria A; Bianco, Federica; Santoro, Domenico; Lacquaniti, Antonio; Romeo, Adolfo; Lucisano, Silvia; Buemi, Antoine; Buemi, Michele
- Abstract
Our aim was to evaluate the role of urotensin II, urantide (urotensin II receptor antagonist) and relaxin-2 on the cellular expression of fibronectin as a surrogate marker for renal fibrosis. We employed LLC- PK1 renal tubular epithelial cells and assessed the influence on the fibrotic process of the above-mentioned substances by using anti-fibronectin antibodies in western blot analysis. The addition of urotensin II increased fibronectin expression. Urantide reduced the positivity for fibronectin caused by urotensin II ( P<.05). The anti-fibrotic action was more evident for relaxin-2 ( P<.01). Also in the model of TGF-β1-induced fibrosis, urantide and, to a greater extent, relaxin-2 were able to significantly lessen fibronectin expression (respectively, P<.05 and P<.01). In conclusion, relaxin-2 may reduce urotensin II-induced renal fibrosis.
- Subjects
RENAL fibrosis; FIBRONECTINS; FIBROSIS; UROTENSINS; RELAXIN; THERAPEUTICS
- Publication
Clinical & Experimental Pharmacology & Physiology, 2017, Vol 44, Issue 10, p1069
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/1440-1681.12798