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- Title
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B<sub>12</sub> status among young Laotian children: a randomized controlled trial.
- Authors
Hinnouho, Guy-Marino; Hampel, Daniela; Shahab-Ferdows, Setareh; Barffour, Maxwell A.; McAnena, Liadhan; Arnold, Charles D.; Ryan Wessells, K.; Kounnavong, Sengchanh; Allen, Lindsay H.; McNulty, Helene; Hess, Sonja Y.
- Abstract
Purpose: To assess the effects of intervention with a daily multiple micronutrient powder (MNP) on thiamine, riboflavin, folate, and B12 status among young Laotian children. Methods: Children (n = 1704) aged 6–23 mo, participating in a double-blind placebo-controlled randomized trial were individually randomized to receive daily either MNP (containing 0.5 mg of thiamine, 0.5 mg riboflavin, 150 μg folic acid, and 0.9 μg vitamin B12 along with 11 other micronutrients) or placebo and followed for ~ 36 weeks. In a randomly selected sub-sample of 260 children, erythrocyte thiamine diphosphate (eThDP), plasma folate and B12 concentrations, and erythrocyte glutathione reductase activation coefficient (EGRac; riboflavin biomarker) were assessed at baseline and endline. Results: There was no treatment effect on endline eThDP concentrations (110.6 ± 8.9 nmol/L in MNP vs. 109.4 ± 8.9 nmol/L in placebo group; p = 0.924), EGRac (1.46 ± 0.3 vs. 1.49 ± 0.3; p = 0.184) and B12 concentrations (523.3 ± 24.6 pmol/L vs. 515.9 ± 24.8 pmol/L; p = 0.678). Likewise, the prevalence of thiamine, riboflavin, and B12 deficiencies did not differ significantly between the two groups. However, endline folate concentration was significantly higher in the MNP compared to the placebo group (28.2 ± 0.8 nmol/L vs 19.9 ± 0.8 nmol/L, respectively; p < 0.001), and correspondingly, the prevalence of folate deficiency was significantly lower in the MNP group (1.6% vs 17.4%; p = 0.015). Conclusions: Compared to a placebo, daily MNP for 9 months increased only folate but not thiamine, riboflavin, or B12 status in young Laotian children. Trial registration: The trial was registered at www.clinicaltrials.gov (NCT02428647) on April 29 2015.
- Subjects
LAOS; VITAMIN B2; VITAMIN B12; FOLIC acid deficiency; DIETARY supplements; TREATMENT effectiveness; RANDOMIZED controlled trials; PRE-tests &; post-tests; COMPARATIVE studies; BLIND experiment; DISEASE prevalence; DESCRIPTIVE statistics; MICRONUTRIENTS; FOLIC acid; VITAMIN B1; STATISTICAL sampling; POWDERS; EVALUATION
- Publication
European Journal of Nutrition, 2022, Vol 61, Issue 7, p3423
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-022-02890-3