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- Title
Peptide YY<sub>3–36</sub> concentration in acute- and long-term recovered anorexia nervosa.
- Authors
Tam, Friederike I.; Seidel, Maria; Boehm, Ilka; Ritschel, Franziska; Bahnsen, Klaas; Biemann, Ronald; Weidner, Kerstin; Roessner, Veit; Ehrlich, Stefan
- Abstract
Purpose: The gut–brain axis could be a possible key factor in the pathophysiology of anorexia nervosa. The neuropeptide peptide YY3–36, secreted by endocrine L cells of the gastrointestinal tract, is a known regulator of appetite and food intake. The objective of this study was to investigate peptide YY3–36 plasma concentrations at different stages of anorexia nervosa in a combined cross-sectional and longitudinal design to differentiate between effects of acute undernutrition and more enduring characteristics. Methods: We measured fasting plasma peptide YY3–36 concentrations in young patients with acute anorexia nervosa (n = 47) and long-term recovered patients (n = 35) cross-sectionally in comparison to healthy control participants (n = 58), and longitudinally over the course of inpatient treatment. Physical activity was controlled as it may modulate peptide YY secretion. Results: There was no group difference in peptide YY3–36 concentration among young acutely underweight anorexia nervosa patients, long-term recovered anorexia nervosa patients, and healthy control participants. Longitudinally, there was no change in peptide YY3–36 concentration after short-term weight rehabilitation. For acute anorexia nervosa patients at admission to treatment, there was a negative correlation between peptide YY3–36 concentration and body mass index. Conclusions: The current study provides additional evidence for a normal basal PYY3–36 concentration in AN. Future studies should study multiple appetite-regulating peptides and their complex interplay and also use research designs including a food challenge.
- Subjects
ANOREXIA nervosa; COMPARATIVE studies; CONVALESCENCE; GASTROINTESTINAL hormones; LONGITUDINAL method; NEUROPEPTIDES; PEPTIDE hormones; BODY mass index; CROSS-sectional method; ACUTE diseases
- Publication
European Journal of Nutrition, 2020, Vol 59, Issue 8, p3791
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-020-02210-7