We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients.
- Authors
Vauloup-Fellous, Christelle; Maylin, Sarah; Périllaud-Dubois, Claire; Brichler, Ségolène; Alloui, Chakib; Gordien, Emmanuel; Rameix-Welti, Marie-Anne; Gault, Elyanne; Moreau, Frédérique; Fourati, Slim; Challine, Dominique; Pawlotsky, Jean-Michel; Houhou-Fidouh, Nadhira; Damond, Florence; Mackiewicz, Vincent; Charpentier, Charlotte; Méritet, Jean-François; Rozenberg, Flore; Podglajen, Isabelle; Marot, Stéphane
- Abstract
We report evaluation of 30 assays' (17 rapid tests (RDTs) and 13 automated/manual ELISA/CLIA assay (IAs)) clinical performances with 2594 sera collected from symptomatic patients with positive SARS-CoV-2 rRT-PCR on a respiratory sample, and 1996 pre-epidemic serum samples expected to be negative. Only 4 RDT and 3 IAs fitted both specificity (> 98%) and sensitivity (> 90%) criteria according to French recommendations. Serology may offer valuable information during COVID-19 pandemic, but inconsistent performances observed among the 30 commercial assays evaluated, which underlines the importance of independent evaluation before clinical implementation.
- Subjects
COVID-19; SARS-CoV-2; COVID-19 testing; COVID-19 pandemic; SEROLOGY
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2021, Vol 40, Issue 10, p2235
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-021-04232-3