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- Title
High‐power laser photobiomodulation therapy for immediate pain relief of refractory oral mucositis.
- Authors
Finfter, Ori; Cohen, Refael; Hanut, Aiham; Gavish, Lilach; Zadik, Yehuda
- Abstract
Purpose: We aimed to evaluate the efficacy of high‐power (class IV) laser photobiomodulation (PBM) therapy for immediate pain relief due to oral mucositis (OM) refractory to recommended first‐line therapy. Methods: This retrospective study included 25 cancer patients with refractory chemotherapy‐ or radiotherapy‐induced OM (16 and 9 patients, respectively) that were treated for pain relief with an intraoral InGaAsP diode laser (power density = 1.4 W/cm2). Pain was self‐assessed immediately before and after laser treatment using a 0‐to‐10 numeric rating scale ([NRS], "0" = no pain, "10" = intolerable pain). Results: Patients reported an immediate decrease in pain following 94% (74 of 79) of the PBM sessions, in 61% (48 sessions) the pain reduction was over 50%, and in 35% (28 sessions) the initial pain was completely eliminated. There were no reports of increased pain post‐PBM. For chemotherapy and radiotherapy‐treated patients, mean reduction in pain NRS post‐PBM was 4.8 ± 2.5 (p < 0.001) and 4.5 ± 2.8 (p = 0.001), indicating a post‐PBM reduction of 72% and 60% of the initial pain level, respectively. The analgesic benefit of PBM remained for a mean of 6.0 ± 5.1 days. One patient reported a transient burning sensation after one PBM session. Conclusions: High‐power laser PBM may provide nonpharmacologic, patient‐friendly, long‐lasting, rapid pain relief for refractory OM.
- Subjects
MUCOSITIS; LASERS; PALLIATIVE treatment; RADIOTHERAPY; RESEARCH funding; ORAL mucosa; RETROSPECTIVE studies; CANKER sores; DESCRIPTIVE statistics; LASER therapy; CANCER chemotherapy; PAIN management; PHOTOBIOMODULATION therapy
- Publication
Oral Diseases, 2024, Vol 30, Issue 4, p2285
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.14618