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- Title
Effect of the Suppressor of Underreplication (SuUR) Gene on Position-Effect Variegation Silencing in Drosophila melanogaster.
- Authors
Belyaeva, E.S.; Boldyreva, L.V.; Volkova, E.I.; Nanayev, R.A.; Alekseyenko, A.A.; Zhimulev, I.F.
- Abstract
It has been previously shown that the SuUR gene encodes a protein located in intercalary and pericentromeric heterochromatin in Drosophila melanogaster polytene chromosomes. The SuUR mutation suppresses the formation of ectopic contacts and DNA underreplication in polytene chromosomes; SuUR[sup +] in extra doses enhances the expression of these characters. This study demonstrates that heterochromatin-dependent PEV silencing is also influenced by SuUR. The SuUR protein localizes to chromosome regions compacted as a result of PEV; the SuUR mutation suppresses DNA underreplication arising in regions of polytene chromosomes undergoing PEV. The SuUR mutation also suppresses variegation of both adult morphological characters and chromatin compaction observed in rearranged chromosomes. In contrast, SuUR[sup +] in extra doses and its overexpression enhance variegation. Thus, SuUR affects PEV silencing in a dose-dependent manner. However, its effect is expressed weaker than that of the strong modifier Su(var)2-5.
- Subjects
DROSOPHILA melanogaster; HETEROCHROMATIN; GENES; PROTEINS; CHROMOSOMES; GENETIC mutation
- Publication
Genetics, 2003, Vol 165, Issue 3, p1209
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1093/genetics/165.3.1209