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- Title
基于氨基酸组分和位点保守信息识别蛋白质 ■HEME结合残基.
- Authors
李彩艳; 马 勇; 邢俊凤; 郭国栋; 武一凡; 闻昊坤; 丁海麦; 张改梅
- Abstract
HEME is an important and commonly used ligand that plays an important role in electron transfer, catalysis, signaling transduction, and gene expression. Accurate prediction of the binding residues of protein-HEME interactions is one of the main challenges in structural bioinformatics. In this study, the information of HEME ligand and protein was downloaded from Biolip database, and amino acid components and site conservative information of binding residues were and nonbinding residues were satistically analyzed and used as prediction characteristic parameters. HEME binding residues were identified by Fisher-PSSM criterion, and calculation results showed that the Fisher-PSSM criterion of optimizing characteristic parameters had good prediction results.
- Subjects
HEMOPROTEINS; STRUCTURAL bioinformatics; CHARGE exchange; HEME; CELLULAR signal transduction
- Publication
Chinese Journal of Bioinformatics, 2022, Vol 20, Issue 3, p189
- ISSN
1672-5565
- Publication type
Article
- DOI
10.12113/202103014