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- Title
The Effects of Concomitant use of Silymarin and Chemotherapy on Solid Tumors: A pilot randomized controlled trial.
- Authors
Sadighi, Sanambar; Dashti-Khavidaki, Simin; Shahbazi, Foroud; Mirzania, Mehrzad; Shahi, Farhad; Abdollahi, Alireza; Ghahremani, Mohammad Hossein
- Abstract
Background: Anti-cancer potential of silymarin has been shown in cell culture. However, no prospective clinical study has been conducted in this relation. Methods: In a randomized double blind pilot study, we compared effects of addition of standard chemotherapy along with silymarin (420mg/day) versus placebo on clinical response of advanced tumors after three cycles of cisplatin-based chemotherapy. Results: There was no significant difference in tumor size after three consecutive chemotherapy courses but a trend toward lower metastasis rate in chemotherapy + silymarin group. Concomitant use of silymarin and chemotherapy was very well tolerated but didn't significantly increase clinical response. Conclusion: Due to the trend towards significantly lower metastasis in silymarin group, further study with larger sample size is needed to better clarify probable role of adjunctive therapy with silymarin in patients with solid tumors.
- Subjects
SILYMARIN; CHEMOTHERAPY complications; TUMOR treatment; RANDOMIZED controlled trials; CELL culture; CISPLATIN
- Publication
Basic & Clinical Cancer Research, 2017, Vol 9, Issue 2, p13
- ISSN
2228-6527
- Publication type
Article