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- Title
Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review.
- Authors
Irimia, Teodora; Dinu-Pîrvu, Cristina-Elena; Ghica, Mihaela Violeta; Popa, Lăcrămioara; Lupuleasa, Dumitru; Muntean, Daniela-Lucia; Udeanu, Denisa Ioana
- Abstract
Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye drops because they associate the advantages of solutions such as accuracy and reproducibility of dosing, or ease of administration with prolonged contact time of ointments. Chitosan is a natural polymer suitable for use in ophthalmic formulations due to its biocompatibility, biodegradability, mucoadhesive character, antibacterial and antifungal properties, permeation enhancement and corneal wound healing effects. The combination of chitosan, pH-sensitive polymer, with other stimuli-responsive polymers leads to increased mechanical strength of formulations and an improved therapeutic effect due to prolonged ocular contact time. This review describes in situ gelling systems resulting from the association of chitosan with various stimuli-responsive polymers with emphasis on the mechanism of gel formation and application in ophthalmology. It also comprises the main techniques for evaluation of chitosan in situ gels, along with requirements of safety and ocular tolerability.
- Subjects
PHARMACEUTICAL gels; OPHTHALMOLOGICAL therapeutics; CHITOSAN; BIOCOMPATIBILITY; ANTI-infective agents; SOL-gel processes
- Publication
Marine Drugs, 2018, Vol 16, Issue 10, p373
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md16100373