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- Title
Heart Rate Predicts the Risk of New-Onset Peripheral Arterial Disease in a Community-Based Population in China.
- Authors
Gao, Yusi; Fan, Fangfang; Jia, Jia; Jiang, Yimeng; He, Danmei; Wu, Zhongli; Huo, Yong; Zhou, Jing; Zhang, Yan
- Abstract
<bold>Introduction: </bold>Elevated heart rate is linked with poor prognosis and has been shown to accelerate the progress of atherosclerosis. However, the association between heart rate and new-onset PAD is unknown.<bold>Methods: </bold>A total of 3463 participants without PAD at baseline from a community-based cohort in Beijing were included and followed up for 2.3 years. PAD was defined as ankle-brachial index (ABI) ≤0.9. We used multivariate logistic regression models to investigate the association of heart rate and the risk of new-onset PAD.<bold>Results: </bold>Participants were 56.67 ± 8.54 years old, and 36.12% were men. The baseline ABI was 1.11 ± 0.08, and the incidence of new-onset PAD was 2.97%. Multivariate regression models, adjusted for sex, age, risk factor of atherosclerosis, medications, and baseline ABI, showed that heart rate was significantly associated with incidence of PAD (odds ratio [OR] = 1.22, 95% confidence interval [CI]: 1.03-1.43, P = 0.020); every increase of 10 heart beats per minute (bpm) was associated with a 22% increase in the odds of developing new-onset PAD. Respondents in the higher-heart rate group (≥80 bpm) had an increased risk of new-onset PAD, compared with those in the lower-heart rate group (<80 bpm) (OR = 1.73, 95% CI: 1.14-2.63, P = 0.010). Subgroup analyses revealed no significant heterogeneity among the analyzed subgroups.<bold>Conclusion: </bold>Elevated heart rate was independently associated with the risk of new-onset PAD in a community-based population in Beijing. Heart rate management should be considered for the purpose of PAD prevention.
- Subjects
BEIJING (China); CHINA; PERIPHERAL vascular diseases; HEART beat; ATHEROSCLEROSIS; POPULATION of China; ANKLE brachial index; LOGISTIC regression analysis
- Publication
Therapeutics & Clinical Risk Management, 2021, Vol 17, p267
- ISSN
1176-6336
- Publication type
journal article
- DOI
10.2147/TCRM.S304491