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- Title
Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial.
- Authors
Esposito K; Giugliano F; Di Palo C; Giugliano G; Marfella R; D'Andrea F; D'Armiento M; Giugliano D; Esposito, Katherine; Giugliano, Francesco; Di Palo, Carmen; Giugliano, Giovanni; Marfella, Raffaele; D'Andrea, Francesco; D'Armiento, Massimo; Giugliano, Dario
- Abstract
<bold>Context: </bold>Healthy lifestyle factors are associated with maintenance of erectile function in men.<bold>Objective: </bold>To determine the effect of weight loss and increased physical activity on erectile and endothelial functions in obese men.<bold>Design, Setting, and Patients: </bold>Randomized, single-blind trial of 110 obese men (body mass index > or =30) aged 35 to 55 years, without diabetes, hypertension, or hyperlipidemia, who had erectile dysfunction that was determined by having a score of 21 or less on the International Index of Erectile Function (IIEF). The study was conducted from October 2000 to October 2003 at a university hospital in Italy.<bold>Interventions: </bold>The 55 men randomly assigned to the intervention group received detailed advice about how to achieve a loss of 10% or more in their total body weight by reducing caloric intake and increasing their level of physical activity. Men in the control group (n = 55) were given general information about healthy food choices and exercise.<bold>Main Outcomes Measures: </bold>Erectile function score, levels of cholesterol and triglycerides, circulating levels of interleukin 6, interleukin 8, and C-reactive protein, and endothelial function as assessed by vascular responses to l-arginine.<bold>Results: </bold>After 2 years, body mass index decreased more in the intervention group (from a mean [SD] of 36.9 [2.5] to 31.2 [2.1]) than in the control group (from 36.4 [2.3] to 35.7 [2.5]) (P<.001), as did serum concentrations of interleukin 6 (P =.03), and C-reactive protein (P =.02). The mean (SD) level of physical activity increased more in the intervention group (from 48 [10] to 195 [36] min/wk; P<.001) than in the control group (from 51 [9] to 84 [28] min/wk; P<.001). The mean (SD) IIEF score improved in the intervention group (from 13.9 [4.0] to 17 [5]; P<.001), but remained stable in the control group (from 13.5 [4.0] to 13.6 [4.1]; P =.89). Seventeen men in the intervention group and 3 in the control group (P =.001) reported an IIEF score of 22 or higher. In multivariate analyses, changes in body mass index (P =.02), physical activity (P =.02), and C-reactive protein (P =.03) were independently associated with changes in IIEF score.<bold>Conclusion: </bold>Lifestyle changes are associated with improvement in sexual function in about one third of obese men with erectile dysfunction at baseline.
- Publication
JAMA: Journal of the American Medical Association, 2004, Vol 291, Issue 24, p2978
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.291.24.2978