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- Title
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium.
- Authors
Moal, Bertrand; Orieux, Arthur; Ferté, Thomas; Neuraz, Antoine; Brat, Gabriel A.; Avillach, Paul; Bonzel, Clara-Lea; Cai, Tianxi; Cho, Kelly; Cossin, Sébastien; Griffier, Romain; Hanauer, David A.; Haverkamp, Christian; Ho, Yuk-Lam; Hong, Chuan; Hutch, Meghan R.; Klann, Jeffrey G.; Le, Trang T.; Loh, Ne Hooi Will; Luo, Yuan
- Abstract
Purpose: In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods: A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results: Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%). Conclusion: Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
- Subjects
YOUNG adults; SARS-CoV-2; ADULT respiratory distress syndrome; ELECTRONIC health records; NEUROENDOCRINE cells; CONSORTIA
- Publication
PLoS ONE, 2023, Vol 17, Issue 1, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0266985