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Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
Published in:
Nature Biotechnology, 2010, v. 28, n. 5, p. 478, doi. 10.1038/nbt.1623
By:
- Vaidya, Vishal S.;
- Ozer, Josef S.;
- Dieterle, Frank;
- Collings, Fitz B.;
- Ramirez, Victoria;
- Troth, Sean;
- Muniappa, Nagaraja;
- Thudium, Douglas;
- Gerhold, David;
- Holder, Daniel J.;
- Bobadilla, Norma A.;
- Marrer, Estelle;
- Parentes, Elias;
- Cordier, André;
- Vonderscher, Jacky;
- Maurer, Gérard;
- Goering, Peter L.;
- Sistare, Frank D.;
- Bonventre, Joseph V.
Publication type:
Article
Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury.
Published in:
Nature Biotechnology, 2010, v. 28, n. 5, p. 470, doi. 10.1038/nbt.1624
By:
- Yan Yu;
- Hong Jin;
- Holder, Daniel;
- Ozer, Josef S.;
- Villarreal, Stephanie;
- Shughrue, Paul;
- Shu Shi;
- Figueroa, David J.;
- Clouse, Holly;
- Ming Su;
- Muniappa, Nagaraja;
- Troth, Sean P.;
- Bailey, Wendy;
- Seng, John;
- Aslamkhan, Amy G.;
- Thudium, Douglas;
- Sistare, Frank D.;
- Gerhold, David L.
Publication type:
Article
Towards consensus practices to qualify safety biomarkers for use in early drug development.
Published in:
Nature Biotechnology, 2010, v. 28, n. 5, p. 446, doi. 10.1038/nbt.1634
By:
- Sistare, Frank D.;
- Dieterle, Frank;
- Troth, Sean;
- Holder, Daniel J.;
- Gerhold, David;
- Andrews-Cleavenger, Dina;
- Baer, William;
- Betton, Graham;
- Bounous, Denise;
- Carl, Kevin;
- Collins, Nathaniel;
- Goering, Peter;
- Goodsaid, Federico;
- Yi-Zhong Gu;
- Guilpin, Valerie;
- Harpur, Ernie;
- Hassan, Alita;
- Jacobson-Kram, David;
- Kasper, Peter;
- Laurie, David
Publication type:
Article
Research at the interface of industry, academia and regulatory science.
Published in:
Nature Biotechnology, 2010, v. 28, n. 5, p. 432, doi. 10.1038/nbt0510-432
By:
- Mattes, William B.;
- Walker, Elizabeth Gribble;
- Abadie, Eric;
- Sistare, Frank D.;
- Vonderscher, Jacky;
- Woodcock, Janet;
- Woosley, Raymond L.
Publication type:
Article
A rapid urine test for early detection of kidney injury.
Published in:
Kidney International, 2009, v. 76, n. 1, p. 108, doi. 10.1038/ki.2009.96
By:
- Vaidya, Vishal S.;
- Ford, Glen M.;
- Waikar, Sushrut S.;
- Yizhuo Wang;
- Clement, Matthew B.;
- Ramirez, Victoria;
- Glaab, Warren E.;
- Troth, Sean P.;
- Sistare, Frank D.;
- Prozialeck, Walter C.;
- Edwards, Joshua R.;
- Bobadilla, Norma A.;
- Mefferd, Stephen C.;
- Bonventre, Joseph V.
Publication type:
Article
Medical applications of microarray technologies: a regulatory science perspective.
Published in:
Nature Genetics, 2002, v. 32, p. 474, doi. 10.1038/ng1029
By:
- Petricoin, Emanuel F.;
- Hackett, Joseph L.;
- Lesko, Lawrence J.;
- Puri, Raj K.;
- Gutman, Steven I.;
- Chumakov, Konstantin;
- Woodcock, Janet;
- Feigal, David W.;
- Zoon, Kathryn C.;
- Sistare, Frank D.
Publication type:
Article
Overview of the Application of Transcription Profiling Using Selected Nephrotoxicants for Toxicology Assessment.
Published in:
Environmental Health Perspectives, 2004, v. 112, n. 4, p. 460, doi. 10.1289/ehp.6673
By:
- Kramer, Jeffrey A.;
- Pettit, Syril D.;
- Amin, Rupesh P.;
- Bertram, Timothy A.;
- Car, Bruce;
- Cunningham, Michael;
- Curtis, Sandra W.;
- Davis, John W.;
- Kind, Clive;
- Lawton, Michael;
- Naciff, Jorge M.;
- Oreffo, Victor;
- Roman, Richard J.;
- Sistare, Frank D.;
- Stevens, James;
- Thompson, Karol;
- Vickers, Alison E.;
- Wild, Stacey;
- Afshari, Cynthia A.
Publication type:
Article
Identification of Platform-Independent Gene Expression Markers of Cisplatin Nephrotoxicity.
Published in:
Environmental Health Perspectives, 2004, v. 112, n. 4, p. 488, doi. 10.1289/ehp.6676
By:
- Thompson, Karol L.;
- Afshari, Cynthia A.;
- Amin, Rupesh P.;
- Bertram, Timothy A.;
- Car, Bruce;
- Cunningham, Michael;
- Kind, Clive;
- Kramer, Jeffrey A.;
- Lawton, Michael;
- Mirsky, Michael;
- Naciff, Jorge M.;
- Oreffo, Victor;
- Pine, P. Scott;
- Sistare, Frank D.
Publication type:
Article
Dye-Bias Correction in Dual-Labeled cDNA Microarray Gene Expression Measurements
Published in:
Environmental Health Perspectives, 2004, v. 112, n. 4, p. 480, doi. 10.1289/ehp.6694
By:
- Rosenzweig, Barry A.;
- Pine, P. Scott;
- Domon, Olen E.;
- Morris, Suzanne M.;
- Chen, James J.;
- Sistare, Frank D.
Publication type:
Article
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats.
Published in:
Toxicologic Pathology, 2024, v. 52, n. 2/3, p. 88, doi. 10.1177/01926233241248656
By:
- Gu, Yi-Zhong;
- Paul, Erina;
- Vlasakova, Katerina;
- Troth, Sean P.;
- Sistare, Frank D.;
- Ramaiah, Lila;
- Potz, Oliver;
- Sutradhar, Santosh;
- Glaab, Warren E.
Publication type:
Article
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.
Published in:
Toxicologic Pathology, 2023, v. 51, n. 1/2, p. 15, doi. 10.1177/01926233231162809
By:
- Gu, Yi-Zhong;
- Vlasakova, Katerina;
- Miller, Glen;
- Gatto, Nicholas T.;
- Ciaccio, Paul J.;
- Kuruvilla, Sabu;
- Besteman, Elizabeth G.;
- Smith, Roger;
- Reynolds, Spencer J.;
- Amin, Rupesh P.;
- Glaab, Warren E.;
- Wollenberg, Gordon;
- Lebron, Jose;
- Sistare, Frank D.
Publication type:
Article
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling.
Published in:
Toxicologic Pathology, 2022, v. 50, n. 1, p. 35, doi. 10.1177/01926233211049171
By:
- Gu, Yi-Zhong;
- Handt, Larry;
- Vlasakova, Katerina;
- Bakthavatchalu, Vasudevan;
- Smith, Roger;
- Fernandez, Guillermo E.;
- Born, Stephanie L.;
- Glaab, Warren E.;
- Sistare, Frank D.
Publication type:
Article
Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates.
Published in:
Toxicologic Pathology, 2020, v. 48, n. 5, p. 633, doi. 10.1177/0192623320932159
By:
- Vlasakova, Katerina;
- Troth, Sean P.;
- Sistare, Frank D.;
- Glaab, Warren E.
Publication type:
Article
Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cellsThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article: 25th anniversary of Environmental and Molecular Mutagenesis
Published in:
Environmental & Molecular Mutagenesis, 2005, v. 45, n. 2/3, p. 188
By:
- Gregory S. Akerman;
- Barry A. Rosenzweig;
- Olen E. Domon;
- Chen‐An Tsai;
- Michelle E. Bishop;
- Lynda J. McGarrity;
- James T. MacGregor;
- Frank D. Sistare;
- James J. Chen;
- Suzanne M. Morris
Publication type:
Article
A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.
Published in:
Toxicology Research, 2024, v. 13, n. 1, p. 1, doi. 10.1093/toxres/tfad120
By:
- Aslamkhan, Amy G;
- Michna, Laura;
- Podtelezhnikov, Alexei;
- Vlasakova, Katerina;
- Suemizu, Hiroshi;
- Ohnishi, Yasuyuki;
- Liu, Liping;
- Lane, Pamela;
- Xu, Qiuwei;
- Kuhls, Matthew C;
- Wang, Zhibin;
- Pacchione, Stephen;
- Erdos, Zoltan;
- Tracy, Rodger William;
- Koeplinger, Kenneth;
- Muniappa, Nagaraja;
- Valentine, John;
- Galijatovic-Idrizbegovic, Alema;
- Glaab, Warren E;
- Sistare, Frank D
Publication type:
Article
What evidence do we need for biomarker qualification?
Published in:
Science Translational Medicine, 2017, v. 9, n. 417, p. 1, doi. 10.1126/scitranslmed.aal4599
By:
- Leptak, Chris;
- Menetski, Joseph P.;
- Wagner, John A.;
- Aubrecht, Jiri;
- Brady, Linda;
- Brumfield, Martha;
- Chin, William W.;
- Hoffmann, Steve;
- Kelloff, Gary;
- Lavezzari, Gabriela;
- Ranganathan, Rajesh;
- Sauer, John-Michael;
- Sistare, Frank D.;
- Zabka, Tanja;
- Wholley, David
Publication type:
Article
Loss of critical palindromic transgene promoter sequence in chemically induced Tg.AC mouse skin papillomas expressing transgene-derived mRNA.
Published in:
Molecular Carcinogenesis, 2001, v. 32, n. 4, p. 176, doi. 10.1002/mc.10009
By:
- Thompson, Karol L.;
- Rosenzweig, Barry A.;
- Honchel, Ronald;
- Cannon, Ronald E.;
- Blanchard, Kerry T.;
- Stoll, Raymond E.;
- Sistare, Frank D.
Publication type:
Article
Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype.
Published in:
Molecular Carcinogenesis, 2001, v. 30, n. 2, p. 99, doi. 10.1002/1098-2744(200102)30:2<99::AID-MC1018>3.0.CO;2-7
By:
- Honchel, Ronald;
- Rosenzweig, Barry A.;
- Thompson, Karol L.;
- Blanchard, Kerry T.;
- Furst, Sylvia M.;
- Stoll, Raymond E.;
- Sistare, Frank D.
Publication type:
Article
Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats.
Published in:
Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 2, p. 303, doi. 10.1007/s00280-009-1164-9
By:
- Thompson, Karol L.;
- Rosenzweig, Barry A.;
- Jun Zhang;
- Knapton, Alan D.;
- Honchel, Ronald;
- Lipshultz, Steven E.;
- Retief, Jacques;
- Sistare, Frank D.;
- Herman, Eugene H.
Publication type:
Article
The Utility of Genetically Modified Mouse Assays for Identifying Human Carcinogens: A Basic Understanding and Path Forward.
Published in:
Toxicological Sciences, 2004, v. 77, n. 2, p. 188, doi. 10.1093/toxsci/kfh037
By:
- MacDonald, James;
- French, John E.;
- Gerson, Ronald J.;
- Goodman, Jay;
- Inoue, Tohru;
- Jacobs, Abigail;
- Kasper, Peter;
- Keller, Douglas;
- Lavin, Amy;
- Long, Gerald;
- McCullough, Bruce;
- Sistare, Frank D.;
- Storer, Richard;
- van der Laan, Jan Willem
Publication type:
Article
Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity.
Published in:
Toxicological Sciences, 2002, v. 68, n. 1, p. 9, doi. 10.1093/toxsci/68.1.9
By:
- Haberny, Kathleen A.;
- Paule, Merle G.;
- Scallet, Andrew C.;
- Sistare, Frank D.;
- Lester, David S.;
- Hanig, Joseph P.;
- Slikker Jr., William
Publication type:
Article
Evaluation of in Vitro Reporter Gene Induction Assays for Use in a Rapid Prescreen for Compound Selection to Test Specificity in the Tg.AC Mouse Short-Term Carcinogenicity Assay.
Published in:
Toxicological Sciences, 2000, v. 57, n. 1, p. 43, doi. 10.1093/toxsci/57.1.43
By:
- Thompson, Karol L.;
- Rosenzweig, Barry A.;
- Tsong, Yi;
- Sistare, Frank D.
Publication type:
Article
Diagnosis of drug-induced renal tubular toxicity using global geneexpression profiles.
Published in:
Journal of Translational Medicine, 2007, v. 5, p. 47, doi. 10.1186/1479-5876-5-47
By:
- Ying Jiang;
- Gerhold, David L.;
- Holder, Daniel J.;
- Figueroa, David J.;
- Bailey, Wendy J.;
- Ping Guan;
- Skopek, Thomas R.;
- Sistare, Frank D.;
- Sina, Joseph F.
Publication type:
Article
Survey of tumorigenic sensitivity in 6-month rasH2-Tg mice studies compared with 2-year rodent assays.
Published in:
Journal of Toxicologic Pathology, 2022, v. 35, n. 1, p. 53, doi. 10.1293/tox.2021-0031
By:
- Shigeru Hisada;
- Kenjiro Tsubota;
- Kenji Inoue;
- Hisaharu Yamada;
- Takanori Ikeda;
- Sistare, Frank D.
Publication type:
Article
ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives.
Published in:
Frontiers in Toxicology, 2024, p. 1, doi. 10.3389/ftox.2024.1377990
By:
- Vahle, John L.;
- Dybowski, Joe;
- Graziano, Michael;
- Shigeru Hisada;
- Lebron, Jose;
- Nolte, Thomas;
- Steigerwalt, Ronald;
- Kenjiro Tsubota;
- Sistare, Frank D.
Publication type:
Article
Performance Assessment of New Urinary Translational Safety Biomarkers of Drug-induced Renal Tubular Injury in Tenofovir-treated Cynomolgus Monkeys and Beagle Dogs.
Published in:
Toxicologic Pathology, 2018, v. 46, n. 5, p. 553, doi. 10.1177/0192623318775023
By:
- Gu, Yi-Zhong;
- Vlasakova, Katerina;
- Troth, Sean P.;
- Peiffer, Robert L.;
- Tournade, Herve;
- Pasello dos Santos, Flavia R.;
- Glaab, Warren E.;
- Sistare, Frank D.
Publication type:
Article
Vascular Imaging of Matrix Metalloproteinase Activity as an Informative Preclinical Biomarker of Drug-induced Vascular Injury.
Published in:
Toxicologic Pathology, 2017, v. 45, n. 5, p. 633, doi. 10.1177/0192623317720731
By:
- Gonzalez, Raymond J.;
- Lin, Shu-An;
- Bednar, Bohumil;
- Connolly, Brett;
- LaFranco-Scheuch, Lisa;
- Mesfin, Gebre M.;
- Philip, Thomas;
- Patel, Shetal;
- Johnson, Timothy;
- Sistare, Frank D.;
- Glaab, Warren E.
Publication type:
Article
Regulatory Forum Commentary Counterpoint: Dose Selection for Tg.rasH2 Mouse Carcinogenicity Studies.
Published in:
Toxicologic Pathology, 2015, v. 43, n. 5, p. 621, doi. 10.1177/0192623315587722
By:
- DARBES, JARIG;
- SISTARE, FRANK D.;
- DEGEORGE, JOSEPH J.
Publication type:
Article
Regulatory Forum Commentary*: Alternative Mouse Models for Future Cancer Risk Assessment.
Published in:
Toxicologic Pathology, 2014, v. 42, n. 5, p. 799, doi. 10.1177/0192623313502130
By:
- Morton, Daniel;
- Sistare, Frank D.;
- Nambiar, Prashant R.;
- Turner, Oliver C.;
- Radi, Zaher;
- Bower, Nancy
Publication type:
Article
An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing: Support for a Proposal to Modify Current Regulatory Guidelines.
Published in:
Toxicologic Pathology, 2011, v. 39, n. 4, p. 716, doi. 10.1177/0192623311406935
By:
- SISTARE, FRANK D.;
- MORTON, DANIEL;
- ALDEN, CARL;
- CHRISTENSEN, JOEL;
- KELLER, DOUGLAS;
- DE JONGHE, SANDRA;
- STORER, RICHARD D.;
- REDDY, M. VIJAYARAJ;
- KRAYNAK, ANDREW;
- TRELA, BRUCE;
- BIENVENU, JEAN-GUY;
- BJURSTRÖM, SIVERT;
- BOSMANS, VANESSA;
- BREWSTER, DAVID;
- COLMAN, KARYN;
- DOMINICK, MARK;
- EVANS, JOHN;
- HAILEY, JAMES R.;
- KINTER, LEWIS;
- LIU, MATT
Publication type:
Article
An Industry Perspective on the Utility of Short-Term Carcinogenicity Testing in Transgenic Mice in Pharmaceutical Development.
Published in:
Toxicologic Pathology, 2010, v. 38, n. 1, p. 51, doi. 10.1177/0192623309351718
By:
- Storer, Richard D.;
- Sistare, Frank D.;
- Vijayaraj Reddy, M.;
- Degeorge, Joseph J.
Publication type:
Article
Biomarkers in Peripheral Blood Associated with Vascular Injury in Sprague-Dawley Rats Treated with the Phosphodiesterase IV Inhibitors SCH 351591 or SCH 534385.
Published in:
Toxicologic Pathology, 2008, v. 36, n. 6, p. 840, doi. 10.1177/0192623308322310
By:
- WEAVER, JAMES L.;
- SNYDER, RONALD;
- KNAPTON, ALAN;
- HERMAN, EUGENE H.;
- HONCHEL, RONALD;
- MILLER, TERRY;
- ESPANDIARI, PARVANEH;
- SMITH, ROGER;
- YI-ZHONG GU;
- GOODSAID, FEDERICO M.;
- ROSENBLUM, IRWIN Y.;
- SISTARE, FRANK D.;
- JUN ZHANG;
- HANIG, JOSEPH
Publication type:
Article
Histopathology of Vascular Injury in Sprague-Dawley Rats Treated with Phosphodiesterase IV Inhibitor SCH 351591 or SCH 534385.
Published in:
Toxicologic Pathology, 2008, v. 36, n. 6, p. 827, doi. 10.1177/0192623308322308
By:
- JUN ZHANG;
- SNYDER, RONALD D.;
- HERMAN, EUGENE H.;
- KNAPTON, ALAN;
- HONCHEL, RONALD;
- MILLER, TERRY;
- ESPANDIARI, PARVANEH;
- GOODSAID, FEDERICO M.;
- ROSENBLUM, IRWIN Y.;
- HANIG, JOSEPH P.;
- SISTARE, FRANK D.;
- WEAVER, JAMES L.
Publication type:
Article
Mechanisms and Biomarkers of Cardiovascular Injury Induced by Phosphodiesterase Inhibitor III SK&F 95654 in the Spontaneously Hypertensive Rat.
Published in:
Toxicologic Pathology, 2006, v. 34, n. 2, p. 152, doi. 10.1080/01926230600588562
By:
- Jun Zhang;
- Herman, Eugene H.;
- Robertson, Donald G.;
- Reily, Michael D.;
- Knapton, Alan;
- Ratajczak, Helen V.;
- Rifal, Nader;
- Honchel, Ronald;
- Blanchard, Kerry T.;
- Stoll, Raymond E.;
- Sistare, Frank D.
Publication type:
Article
Toxicoproteomics: Serum Proteomic Pattern Diagnostics for Early Detection of Drug Induced Cardiac Toxicities and Cardioprotection.
Published in:
Toxicologic Pathology, 2004, v. 32, p. 122, doi. 10.1080/01926230490426516
By:
- Petricoin, Emanuel F.;
- Rajapaske, Vinodh;
- Herman, Eugene H.;
- Arekani, Ali M.;
- Ross, Sally;
- Johann, Donald;
- Knapton, Alan;
- Zhang, J.;
- Hitt, Ben A.;
- Conrads, Thomas P.;
- Veenstra, Timothy D.;
- Liotta, Lance A.;
- Sistare, Frank D.
Publication type:
Article
Use of Transgenic Mice in Carcinogenicity Hazard Assessment.
Published in:
Toxicologic Pathology, 2004, v. 32, p. 49, doi. 10.1080/01926230490424761
By:
- Jacobson-Kram, David;
- Sistare, Frank D.;
- Jacobs, Abigail C.
Publication type:
Article
Toxicoproteomics: Serum Proteomic Pattern Diagnostics for Early Detection of Drug Induced Cardiac Toxicities and Cardioprotection.
Published in:
Toxicologic Pathology, 2004, v. 32, n. 1S, p. 122, doi. 10.1080/01926230490426516
By:
- Petricoin, Emanuel F.;
- Rajapaske, Vinodh;
- Herman, Eugene H.;
- Arekani, Ali M.;
- Ross, Sally;
- Johann, Donald;
- Knapton, Alan;
- Zhang, J.;
- Hitt, Ben A.;
- Conrads, Thomas P.;
- Veenstra, Timothy D.;
- Liotta, Lance A.;
- Sistare, Frank D.
Publication type:
Article
Use of Transgenic Mice in Carcinogenicity Hazard Assessment.
Published in:
Toxicologic Pathology, 2004, v. 32, n. 1S, p. 49, doi. 10.1080/01926230490424761
By:
- Jacobson-Kram, David;
- Sistare, Frank D.;
- Jacobs, Abigail C.
Publication type:
Article
Serum Troponins as Biomarkers of Drug-Induced Cardiac Toxicity.
Published in:
Toxicologic Pathology, 2004, v. 32, n. 1, p. 106, doi. 10.1080/01926230490261302
By:
- Wallace, Kendall B.;
- Hausner, Elizabeth;
- Herman, Eugene;
- Holt, Gordon D.;
- MacGregor, James T.;
- Metz, Alan L.;
- Murphy, Elizabeth;
- Rosenblaum, I. Y.;
- Sistare, Frank D.;
- York, Malcolm J.
Publication type:
Article
SK&F 95654-Induced Acute Cardiovascular Toxicity in Sprague-Dawley Rats—Histopathologic, Electron Microscopic, and Immunohistochemical Studies.
Published in:
Toxicologic Pathology, 2002, v. 30, n. 1, p. 28, doi. 10.1080/01926230252824680
By:
- Zhang, Jun;
- Herman, Eugene H.;
- Knapton, Alan;
- Chadwick, Douglas P.;
- Whitehurst, Virgil E.;
- Koerner, John E.;
- Papoian, Thomas;
- Ferrans, Victor J.;
- Sistare, Frank D.
Publication type:
Article
An Evaluation of the Hemizygous Transgenic Tg.AC Mouse for Carcinogenicity Testing of Pharmaceuticals. I. Evidence for a Confounding Nonresponder Phenotype
Published in:
Toxicologic Pathology, 1998, v. 26, n. 4, p. 532
By:
- Weaver, James L.;
- Contrera, Joseph-P.;
- Thompson, Karol L.;
- Strong, John M.;
- Ellison, Christopher D.;
- Anderson, Lawrence W.;
- Prasanna, Hullahalli R.;
- Long-Bradley, Patricia E.;
- Lin, Karl K.;
- Zhang, Jun;
- Sistare, Frank D.
Publication type:
Article
An Evaluation of the Hemizygous Transgenic Tg.AC Mouse for Carcinogenicity Testing of Pharmaceuticals. II. A Genotypic Marker that Predicts Tumorigenic Responsiveness
Published in:
Toxicologic Pathology, 1998, v. 26, n. 4, p. 548
By:
- Thompson, Karol L.;
- Rosenzweig, Barry A.;
- Sistare, Frank D.
Publication type:
Article
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin.
Published in:
Toxicological Sciences, 2022, v. 187, n. 2, p. 219, doi. 10.1093/toxsci/kfac030
By:
- Vlasakova, Katerina;
- Bourque, Jennifer;
- Bailey, Wendy J;
- Patel, Shetal;
- Besteman, Elizabeth G;
- Gonzalez, Raymond J;
- Sistare, Frank D;
- Glaab, Warren E
Publication type:
Article
Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
Published in:
Toxicological Sciences, 2022, v. 188, n. 1, p. 4, doi. 10.1093/toxsci/kfac041
By:
- Corton, J Christopher;
- Mitchell, Constance A;
- Auerbach, Scott;
- Bushel, Pierre;
- Ellinger-Ziegelbauer, Heidrun;
- Escobar, Patricia A;
- Froetschl, Roland;
- Harrill, Alison H;
- Johnson, Kamin;
- Klaunig, James E;
- Pandiri, Arun R;
- Podtelezhnikov, Alexei A;
- Rager, Julia E;
- Tanis, Keith Q;
- Laan, Jan Willem van der;
- Vespa, Alisa;
- Yauk, Carole L;
- Pettit, Syril D;
- Sistare, Frank D
Publication type:
Article
Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats.
Published in:
Toxicological Sciences, 2021, v. 181, n. 2, p. 148, doi. 10.1093/toxsci/kfab038
By:
- Glaab, Warren E;
- Holder, Daniel;
- He, Yudong D;
- Bailey, Wendy J;
- Gerhold, David L;
- Beare, Carolann;
- Erdos, Zoltan;
- Lane, Pamela;
- Michna, Laura;
- Muniappa, Nagaraja;
- Lawrence, Jeffrey W;
- Tanis, Keith Q;
- Sina, Joseph F;
- Skopek, Thomas R;
- Sistare, Frank D
Publication type:
Article
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.
Published in:
Toxicological Sciences, 2020, v. 177, n. 1, p. 121, doi. 10.1093/toxsci/kfaa094
By:
- Kang, Wen;
- Podtelezhnikov, Alexei A;
- Tanis, Keith Q;
- Pacchione, Stephen;
- Su, Ming;
- Bleicher, Kimberly B;
- Wang, Zhibin;
- Laws, George M;
- Griffiths, Thomas G;
- Kuhls, Matthew C;
- Chen, Qing;
- Knemeyer, Ian;
- Marsh, Donald J;
- Mitra, Kaushik;
- Lebron, Jose;
- Sistare, Frank D
Publication type:
Article
Mechanistic Investigations Support Liver Safety of Ubrogepant.
Published in:
Toxicological Sciences, 2020, v. 177, n. 1, p. 84, doi. 10.1093/toxsci/kfaa093
By:
- Smith, Brenda;
- Rowe, Josh;
- Watkins, Paul B;
- Ashina, Messoud;
- Woodhead, Jeffrey L;
- Sistare, Frank D;
- Goadsby, Peter J
Publication type:
Article
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
Published in:
Toxicological Sciences, 2020, v. 177, n. 1, p. 281, doi. 10.1093/toxsci/kfaa088
By:
- Monroe, James J;
- Tanis, Keith Q;
- Podtelezhnikov, Alexei A;
- Nguyen, Truyen;
- Machotka, Sam V;
- Lynch, Donna;
- Evers, Raymond;
- Palamanda, Jairam;
- Miller, Randy R;
- Pippert, Todd;
- Cabalu, Tamara D;
- Johnson, Timothy E;
- Aslamkhan, Amy G;
- Kang, Wen;
- Tamburino, Alex M;
- Mitra, Kaushik;
- Agrawal, Nancy G B;
- Sistare, Frank D
Publication type:
Article
Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities.
Published in:
Toxicological Sciences, 2020, v. 175, n. 1, p. 98, doi. 10.1093/toxsci/kfaa026
By:
- Podtelezhnikov, Alexei A;
- Monroe, James J;
- Aslamkhan, Amy G;
- Pearson, Kara;
- Qin, Chunhua;
- Tamburino, Alex M;
- Loboda, Andrey P;
- Glaab, Warren E;
- Sistare, Frank D;
- Tanis, Keith Q
Publication type:
Article
Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.
Published in:
Toxicological Sciences, 2019, v. 172, n. 1, p. 155, doi. 10.1093/toxsci/kfz186
By:
- Gu, Yi-Zhong;
- Chu, Xiaoyan;
- Houle, Robert;
- Vlasakova, Katerina;
- Koeplinger, Kenneth A;
- Bourgeois, Isabelle;
- Palyada, Kiran;
- Anderson, Kenneth D;
- Brynczka, Christopher;
- Bhatt, Bhavana;
- Chen, Feifei;
- Smith, Roger;
- Amin, Rupesh;
- Glaab, Warren E;
- Lebron, Jose;
- Cox, Kathleen;
- Sistare, Frank D
Publication type:
Article

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