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- Title
The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough.
- Authors
Heidelberg, John F.; Seshadri, Rekha; Haveman, Shelley A.; Hemme, Christopher L.; Paulsen, Ian T.; Kolonay, James F.; Eisen, Jonathan A.; Ward, Naomi; Methe, Barbara; Brinkac, Lauren M.; Daugherty, Sean C.; Deboy, Robert T.; Dodson, Robert J.; Durkin, A. Scott; Madupu, Ramana; Nelson, William C.; Sullivan, Steven A.; Fouts, Derrick; Haft, Daniel H.; Selengut, Jeremy
- Abstract
<em>Desulfovibrio vulgaris</em> Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the `hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-Ill protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.
- Subjects
DESULFOVIBRIO; GENOMES; CYTOCHROMES; BIOREMEDIATION; METABOLISM; ENZYMES
- Publication
Nature Biotechnology, 2004, Vol 22, Issue 5, p554
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt959