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- Title
Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands.
- Authors
Becker, Andreas; Hessenius, Carsten; Licha, Kai; Ebert, Bernd; Sukowski, Uwe; Semmler, Wolfhard; Wiedenmann, Bertram; Grötzinger, Carsten
- Abstract
We report here the in vivo diagnostic use of a peptide -- dye conjugate consisting of a cyanine dye and the somatostatin analog octreotate as a contrast agent for optical tumor imaging. When used in whole-body in vivo imaging of mouse xenografts, indotricarbocyanine-octreotate accumulated in tumor tissue. Tumor fluorescence rapidly increased and was more than threefold higher than that of normal tissue from 3 to 24 h after application. The targeting conjugate was also specifically internalized by primary human neuroendocrine tumor cells. This imaging approach, combining the specificity of ligand/receptor interaction with near-infrared fluorescence detection, may be applied in various other fields of cancer diagnosis.
- Subjects
TUMORS; IMAGING of cancer
- Publication
Nature Biotechnology, 2001, Vol 19, Issue 4, p327
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/86707