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- Title
Dietary Taurine Supplementation Prevents Glial Alterations in Retina of Diabetic Rats.
- Authors
Kaihong Zeng; Hongxia Xu; Mantian Mi; Qianyong Zhang; Yajie Zhang; Ka Chen; Fang Chen; Jundong Zhu; Xiaoping Yu
- Abstract
Abstract The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and -amino butyric acid (GABA) and expression of glial fibrillary acid protein (GFAP), vascular endothelial growth factor (VEGF), glutamate transporter (GLAST), glutamine synthetase (GS) and glutamate decarboxylase (GAD) in retina were determined in diabetic rats fed without or with 5% taurine in a controlled trial lasting 12 weeks, with normal rats fed without or with 5% taurine served as controls. Dietary taurine supplementation could not lower glucose concentration in blood (P > 0.05), but caused an elevation of taurine content and a decline in levels of glutamate and GABA in retina of diabetic rats (P P
- Subjects
DIETARY supplements; NEUROGLIA; TAURINE; RETINA cytology; STREPTOZOTOCIN; DIABETES; LABORATORY rats; GABA
- Publication
Neurochemical Research, 2009, Vol 34, Issue 2, p244
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-008-9763-0