We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer.
- Authors
Márquez-González, Rosa María; Saucedo-Sariñana, Anilú Margarita; de Jesús Tovar-Jacome, César; Barros-Núñez, Patricio; Gallegos-Arreola, Martha Patricia; Orozco-Gutiérrez, Mario Humberto; Mariscal-Ramírez, Ignacio; Pineda-Razo, Tomas Daniel; Alcaraz-Wong, Aldo Antonio; Marín-Contreras, María Eugenia; Rosales-Reynoso, Mónica Alejandra
- Abstract
Background: Colorectal cancer (CRC) ranks third in cancer incidence globally and is the second leading cause of cancer-related mortality. The nucleoside diphosphate kinase 1 (NME1) and netrin 1 receptor (DCC) genes have been associated with resistance against tumorigenesis and tumor metastasis. This study investigates the potential association between NME1 (rs34214448 G > T and rs2302254 C > T) and DCC (rs2229080 G > C and rs714 A > G) variants and susceptibility to colorectal cancer development. Methods: Samples from 232 colorectal cancer patients and 232 healthy blood donors underwent analysis. Variants were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) methodology. Associations were assessed using odds ratios (OR), and the p values were adjusted with Bonferroni test. Results: Individuals carrying the G/T and T/T genotypes for the NME1 rs34214448 variant exhibited a higher susceptibility for develop colorectal cancer (OR = 2.68, 95% CI: 1.76–4.09, P = 0.001 and OR = 2.47, 95% CI: 1.37–4.47, P = 0.001, respectively). These genotypes showed significant associations in patients over 50 years (OR = 2.87, 95% CI: 1.81–4.54, P = 0.001 and OR = 2.99, 95% CI: 1.54–5.79, P = 0.001 respectively) and with early Tumor-Nodule-Metastasis (TNM) stage (P = 0.001), and tumor location in the rectum (P = 0.001). Furthermore, the DCC rs2229080 variant revealed that carriers of the G/C genotype had an increased risk for develop colorectal cancer (OR = 2.00, 95% CI: 1.28–3.11, P = 0.002) and were associated with age over 50 years, sex, and advanced TNM stages (P = 0.001). Conclusions: These findings suggest that the NME1 rs34214448 and DCC rs2229080 variants play a significant role in colorectal cancer development.
- Subjects
COLORECTAL cancer; MEXICANS; CANCER patients; CANCER-related mortality; RECTUM tumors
- Publication
Journal of the Egyptian National Cancer Institute, 2024, Vol 36, Issue 1, p1
- ISSN
1110-0362
- Publication type
Article
- DOI
10.1186/s43046-024-00213-7