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- Title
Cluster of differentiation 45 activation is crucial in interleukin-10-dependent tumor-associated dendritic cell differentiation.
- Authors
DA-EN CHENG; YING-MING TSAI; YA-LING HSU; MING-FENG HOU; EING-MEI TSAI; JAW-YUAN WANG; JUNG-YU KAN; PO-LIN KUO
- Abstract
Tumor-associated dendritic cells (TADCs) are important in tumor immune surveillance, and it has been reported that the secretion of interleukin (IL)-10 by cancer cells is a major factor involved in the induction of TADCs in the tumor microenvironment. In the present study, IL-10 was found to activate cluster of differentiation (CD)45 protein tyrosine phosphatase (PTPase), inducing a TADC-like phenomenon. The PTPase inhibitor, phenylarsine oxide, and a CD45 inhibitor reversed the IL-10-induced impaired differentiation of the DCs, and also reversed the induction of the TADCs by A549, MDA-MB-231 and SW480 conditioned media, which thus represents a novel therapy to reduce immune surveillance in the tumor microenvironment. The present study is the first to identify that CD45 is involved in IL-10-activated signaling in myeloid lineage cells.
- Subjects
CANCER cell differentiation; DENDRITIC cells; INTERLEUKIN-10; CANCER immunology; PROTEIN-tyrosine phosphatase; PUBLIC health surveillance
- Publication
Oncology Letters, 2014, Vol 8, Issue 2, p620
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2014.2161