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- Title
Cooperative Regulation of the Host Defense to Cryptococcal Infection by Innate Immune Lymphocytes.
- Authors
Kinjo, Takeshi; Fujita, Jiro; Kawakami, Kazuyoshi
- Abstract
Cryptococcus neoformans is an opportunistic fungal infectious pathogen in immunocompromised patients with acquired immunodeficiency syndrome and hematological malignancies. Recently, innate immune cells, such as NK, NKT and γ δ T cells, have been found critical for determining the quality of acquired immunity by affecting the direction of Th1-Th2 balance. Th1-type immune response is important for the host defense against C. neoformans, and innate immunity may involve this process. In the present review, the accumulated knowledge including our own data on the role of innate immune lymphocytes in the host defense to this fungal pathogen are summarized, focusing on NKT and γ δ T cells.
- Subjects
CRYPTOCOCCUS; MYCOSES; AIDS; CELLS; LYMPHOCYTES
- Publication
Japanese Journal of Medical Mycology, 2006, Vol 47, Issue 3, p201
- ISSN
0916-4804
- Publication type
Article
- DOI
10.3314/jjmm.47.201