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- Title
Interleukin 10 Release During Endotoxaemia in Chimpanzees: Role of Platelet-Activating Factor and Interleukin 6.
- Authors
Van Der Poll, Tom; Jansen, J.; Levi, M.; Ten Cate, H.; Hack, C. E.; Aarden, L. A.; Ten Cate, J. W.; Van Deventer, S. J. H.
- Abstract
Interleukin (IL-)10 has been demonstrated to inhibit endotoxin-induced production of a number of pro-inflammatory cytokines. The present study sought to compare the appearances in the circulation of IL-10, IL-6 and IL-8, and to assess the roles of endogenously produced platelet-activating factor (PAF) and IL-6 in IL-10 release during endotoxaemia in chimpanzees. Intravenous injection of endotoxin (lot EC-5, 4 ng/kg, n = 8) induced a transient rise in serum IL-10 concentrations, peaking after 2 h (213 ± 70 pg/ml; P < 0.05). No correlations existed between peak IL-10 levels, and peak IL-6 and IL-8 levels. Neither infusion of the specific PAF antagonist TCV-309 (n = 4), nor infusion of a neutralizing anti-IL-6 monoclonal antibody (n = 4) influenced endotoxin-induced IL-10 release. IL-10 release elicited by injection of endotoxin is not mediated by PAF or IL6.
- Subjects
INTERLEUKINS; PLATELET activating factor; CHIMPANZEES; ENDOTOXINS; CYTOKINES
- Publication
Scandinavian Journal of Immunology, 1996, Vol 43, Issue 1, p122
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1996.d01-12.x