We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of the renal sympathetic nerves in renal sodium/potassium handling and renal damage in spontaneously hypertensive rats.
- Authors
JIANLING LI; QIAOLING HE; WEIFENG WU; QINGJIE LI; RONGJIE HUANG; XIAOFENG PAN; WENYING LAI
- Abstract
Renal sympathetic nerve activity has an important role in renal disease-associated hypertension and in the modulation of fluid homeostasis. In the present study, changes in renal function and renal sodium/potassium handling were investigated in groups of 12-week-old male, spontaneously hypertensive rats with renal denervation (RDNX group) or sham denervation (sham group). The RDNX group excreted significantly more sodium than the sham group during the 2-week observation period (P<0.05). Following bilateral renal denervation, the fractional lithium excretion was elevated in the RDNX group compared with the sham group, but no significant effect was observed of renal denervation on the fractional distal reabsorption rate of sodium or the fractional excretion of potassium. Furthermore, the glomerular injury score and the wall-to-lumen ratio of the interlobular artery were significantly lower in the RDNX group than in the sham group (P<0.05). In conclusion, the present study indicates an involvement of the renal sympathetic nerves in the regulation of renal tubular sodium reabsorption in spontaneously hypertensive rats and in the renal damage associated with hypertension.
- Subjects
KIDNEY injuries; SYMPATHETIC nervous system physiology; SODIUM in the body; POTASSIUM in the body; HYPERTENSION; LABORATORY rats
- Publication
Experimental & Therapeutic Medicine, 2016, Vol 12, Issue 4, p2547
- ISSN
1792-0981
- Publication type
Article
- DOI
10.3892/etm.2016.3669